Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma
Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate its correlation with clinicopathological features and prognosis. Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth...
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| Veröffentlicht in: | Clinical cancer research 2003-12, Vol.9 (16), p.5996 |
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| container_title | Clinical cancer research |
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| creator | Yi Ren Ronnie Tung-Ping Poon Hong-Teng Tsui Wen-Hong Chen Zhi Li Cecilia Lau Wun-Ching Yu Sheung-Tat Fan |
| description | Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate
its correlation with clinicopathological features and prognosis.
Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth factor, and macrophage migration inhibitory
factor in preoperative sera of 59 patients with resection of HCC and 15 healthy subjects.
Results: Preoperative serum IL-8 was found to be significantly elevated in patients with HCC compared with healthy subjects (median,
17.6 versus 1.0 pg/ml, P = 0.046). The levels of IL-8 correlated significantly with a large tumor size (>5 cm), absence of tumor capsule, presence
of venous invasion, and advanced pathological tumor-node-metastasis stage. Serum IL-8 level was a significant prognostic factor
in terms of disease-free and overall survival. Patients with a serum IL-8 level of >17.6 pg/ml had a poorer disease-free survival
than those with a level of |
| format | Article |
| fullrecord | <record><control><sourceid>highwire</sourceid><recordid>TN_cdi_highwire_cancerresearch_9_16_5996</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>9_16_5996</sourcerecordid><originalsourceid>FETCH-highwire_cancerresearch_9_16_59963</originalsourceid><addsrcrecordid>eNqVi70OgjAYABujEfx5h44uJC20BWbUYOJgojtpyKetlmLaIq8vgy_gdDfczVBMOc-TLBV8PjnJi4SwLI3QyvsnIZRRwpYookzkgqY8RvuTDeAMDC9tkwJfwQ0dPsMHjMfa4osMGmzweNRB4RreMvQtGDMY6XAlXatt38kNWtyl8bD9cY12x8OtqhOlH2rUDppW2hacAw_To5qyoaLhZSmyP9IvKKJCDg</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><source>Alma/SFX Local Collection</source><creator>Yi Ren ; Ronnie Tung-Ping Poon ; Hong-Teng Tsui ; Wen-Hong Chen ; Zhi Li ; Cecilia Lau ; Wun-Ching Yu ; Sheung-Tat Fan</creator><creatorcontrib>Yi Ren ; Ronnie Tung-Ping Poon ; Hong-Teng Tsui ; Wen-Hong Chen ; Zhi Li ; Cecilia Lau ; Wun-Ching Yu ; Sheung-Tat Fan</creatorcontrib><description>Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate
its correlation with clinicopathological features and prognosis.
Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth factor, and macrophage migration inhibitory
factor in preoperative sera of 59 patients with resection of HCC and 15 healthy subjects.
Results: Preoperative serum IL-8 was found to be significantly elevated in patients with HCC compared with healthy subjects (median,
17.6 versus 1.0 pg/ml, P = 0.046). The levels of IL-8 correlated significantly with a large tumor size (>5 cm), absence of tumor capsule, presence
of venous invasion, and advanced pathological tumor-node-metastasis stage. Serum IL-8 level was a significant prognostic factor
in terms of disease-free and overall survival. Patients with a serum IL-8 level of >17.6 pg/ml had a poorer disease-free survival
than those with a level of <17.6 pg/ml (median disease-free survival 4.7 versus 19.2 months). Multivariate analyses showed that serum IL-8 level was a significant and independent prognostic factor of survival.
Conclusions: Significant correlations of serum IL-8 levels with tumor size and tumor stage suggest that IL-8 may be directly or indirectly
involved in the progression of HCC. These findings indicate that serum IL-8 may be a useful biological marker of tumor invasiveness
and an independent prognostic factor for patients with HCC.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 14676125</identifier><language>eng</language><publisher>American Association for Cancer Research</publisher><ispartof>Clinical cancer research, 2003-12, Vol.9 (16), p.5996</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids></links><search><creatorcontrib>Yi Ren</creatorcontrib><creatorcontrib>Ronnie Tung-Ping Poon</creatorcontrib><creatorcontrib>Hong-Teng Tsui</creatorcontrib><creatorcontrib>Wen-Hong Chen</creatorcontrib><creatorcontrib>Zhi Li</creatorcontrib><creatorcontrib>Cecilia Lau</creatorcontrib><creatorcontrib>Wun-Ching Yu</creatorcontrib><creatorcontrib>Sheung-Tat Fan</creatorcontrib><title>Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma</title><title>Clinical cancer research</title><description>Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate
its correlation with clinicopathological features and prognosis.
Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth factor, and macrophage migration inhibitory
factor in preoperative sera of 59 patients with resection of HCC and 15 healthy subjects.
Results: Preoperative serum IL-8 was found to be significantly elevated in patients with HCC compared with healthy subjects (median,
17.6 versus 1.0 pg/ml, P = 0.046). The levels of IL-8 correlated significantly with a large tumor size (>5 cm), absence of tumor capsule, presence
of venous invasion, and advanced pathological tumor-node-metastasis stage. Serum IL-8 level was a significant prognostic factor
in terms of disease-free and overall survival. Patients with a serum IL-8 level of >17.6 pg/ml had a poorer disease-free survival
than those with a level of <17.6 pg/ml (median disease-free survival 4.7 versus 19.2 months). Multivariate analyses showed that serum IL-8 level was a significant and independent prognostic factor of survival.
Conclusions: Significant correlations of serum IL-8 levels with tumor size and tumor stage suggest that IL-8 may be directly or indirectly
involved in the progression of HCC. These findings indicate that serum IL-8 may be a useful biological marker of tumor invasiveness
and an independent prognostic factor for patients with HCC.</description><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVi70OgjAYABujEfx5h44uJC20BWbUYOJgojtpyKetlmLaIq8vgy_gdDfczVBMOc-TLBV8PjnJi4SwLI3QyvsnIZRRwpYookzkgqY8RvuTDeAMDC9tkwJfwQ0dPsMHjMfa4osMGmzweNRB4RreMvQtGDMY6XAlXatt38kNWtyl8bD9cY12x8OtqhOlH2rUDppW2hacAw_To5qyoaLhZSmyP9IvKKJCDg</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Yi Ren</creator><creator>Ronnie Tung-Ping Poon</creator><creator>Hong-Teng Tsui</creator><creator>Wen-Hong Chen</creator><creator>Zhi Li</creator><creator>Cecilia Lau</creator><creator>Wun-Ching Yu</creator><creator>Sheung-Tat Fan</creator><general>American Association for Cancer Research</general><scope/></search><sort><creationdate>20031201</creationdate><title>Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma</title><author>Yi Ren ; Ronnie Tung-Ping Poon ; Hong-Teng Tsui ; Wen-Hong Chen ; Zhi Li ; Cecilia Lau ; Wun-Ching Yu ; Sheung-Tat Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-highwire_cancerresearch_9_16_59963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yi Ren</creatorcontrib><creatorcontrib>Ronnie Tung-Ping Poon</creatorcontrib><creatorcontrib>Hong-Teng Tsui</creatorcontrib><creatorcontrib>Wen-Hong Chen</creatorcontrib><creatorcontrib>Zhi Li</creatorcontrib><creatorcontrib>Cecilia Lau</creatorcontrib><creatorcontrib>Wun-Ching Yu</creatorcontrib><creatorcontrib>Sheung-Tat Fan</creatorcontrib><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yi Ren</au><au>Ronnie Tung-Ping Poon</au><au>Hong-Teng Tsui</au><au>Wen-Hong Chen</au><au>Zhi Li</au><au>Cecilia Lau</au><au>Wun-Ching Yu</au><au>Sheung-Tat Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma</atitle><jtitle>Clinical cancer research</jtitle><date>2003-12-01</date><risdate>2003</risdate><volume>9</volume><issue>16</issue><spage>5996</spage><pages>5996-</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate
its correlation with clinicopathological features and prognosis.
Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth factor, and macrophage migration inhibitory
factor in preoperative sera of 59 patients with resection of HCC and 15 healthy subjects.
Results: Preoperative serum IL-8 was found to be significantly elevated in patients with HCC compared with healthy subjects (median,
17.6 versus 1.0 pg/ml, P = 0.046). The levels of IL-8 correlated significantly with a large tumor size (>5 cm), absence of tumor capsule, presence
of venous invasion, and advanced pathological tumor-node-metastasis stage. Serum IL-8 level was a significant prognostic factor
in terms of disease-free and overall survival. Patients with a serum IL-8 level of >17.6 pg/ml had a poorer disease-free survival
than those with a level of <17.6 pg/ml (median disease-free survival 4.7 versus 19.2 months). Multivariate analyses showed that serum IL-8 level was a significant and independent prognostic factor of survival.
Conclusions: Significant correlations of serum IL-8 levels with tumor size and tumor stage suggest that IL-8 may be directly or indirectly
involved in the progression of HCC. These findings indicate that serum IL-8 may be a useful biological marker of tumor invasiveness
and an independent prognostic factor for patients with HCC.</abstract><pub>American Association for Cancer Research</pub><pmid>14676125</pmid></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| title | Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma |
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