JS-K, a Glutathione/Glutathione S-Transferase-activated Nitric Oxide Donor of the Diazeniumdiolate Class with Potent Antineoplastic Activity1

We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation and apoptosis in acute myeloid leukemia cells, with the HL-60 human myeloid leukemia line being particularly sensitive to NO-mediated cytolysis. With the goal of identifying a prodrug that can target NO to th...

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Veröffentlicht in:	Molecular cancer therapeutics 2003-04, Vol.2 (4), p.409
Hauptverfasser:	Paul J. Shami, Joseph E. Saavedra, Lai Y. Wang, Challice L. Bonifant, Bhalchandra A. Diwan, Shivendra V. Singh, Yijun Gu, Stephen D. Fox, Gregory S. Buzard, Michael L. Citro, David J. Waterhouse, Keith M. Davies, Xinhua Ji, Larry K. Keefer
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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