Novel Extranuclear-targeted Anthracyclines Override the Antiapoptotic Functions of Bcl-2 and Target Protein Kinase C Pathways to Induce Apoptosis 1 Supported in part by grants from The Susan G. Komen Breast Cancer Foundation (to L. L.) and NIH (to J. L. C.), and by the American Lebanese Syrian Associated Charities (ALSAC) of St. Jude Children’s Research Hospital.1

Novel Extranuclear-targeted Anthracyclines Override the Antiapoptotic Functions of Bcl-2 and Target Protein Kinase C Pathways to Induce Apoptosis 1 Supported in part by grants from The Susan G. Komen Breast Cancer Foundation (to L. L.) and NIH (to J. L. C.), and by the American Lebanese Syrian Associated Charities (ALSAC) of St. Jude Children’s Research Hospital.1

Bcl-2 inhibits apoptosis induced by numerous antitumor drugs, including doxorubicin and daunorubicin and is, thus, a major impediment to successful cancer chemotherapy. Here, we report the ability of a novel family of nonnuclear targeted anthracyclines to induce rapid apoptosis in cells despite Bcl-...

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Veröffentlicht in:Molecular cancer therapeutics 2002-05, Vol.1 (7), p.469
Hauptverfasser: Christina M. Barrett, Felicia L. Lewis, J. Brent Roaten, Trevor W. Sweatman, Mervyn Israel, John L. Cleveland, Leonard Lothstein
Format: Artikel
Sprache:eng
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