GLEPP1/Protein-tyrosine Phosphatase ϕ Inhibitors Block Chemotaxis in Vitro and in Vivo and Improve Murine Ulcerative Colitis

We describe novel, cell-permeable, and bioavailable salicylic acid derivatives that are potent and selective inhibitors of GLEPP1/protein-tyrosine phosphatase ϕ. Two previously described GLEPP1 substrates, paxillin and Syk, are both required for cytoskeletal rearrangement and cellular motility of l...

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Veröffentlicht in:	The Journal of biological chemistry 2009-04, Vol.284 (17), p.11385
Hauptverfasser:	Rosanna Pescini Gobert, Monique van den Eijnden, Cedric Szyndralewiez, Catherine Jorand-Lebrun, Dominique Swinnen, Linfeng Chen, Corine Gillieron, Fiona Pixley, Pierre Juillard, Patrick Gerber, Caroline Johnson-Léger, Serge Halazy, Montserrat Camps, Agnes Bombrun, Margaret Shipp, Pierre-Alain Vitte, Vittoria Ardissone, Chiara Ferrandi, Dominique Perrin, Christian Rommel, Rob Hooft van Huijsduijnen
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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