Pre-steady-state Kinetic Studies Establish Entecavir 5′-Triphosphate as a Substrate for HIV-1 Reverse Transcriptase

The novel 2′-deoxyguanosine analog Entecavir (ETV) is a potent inhibitor of hepatitis B virus (HBV) replication and is recommended for treatment in human immunodeficiency virus type 1 (HIV-1) and HBV-co-infected patients because it had been reported that ETV is HBV-specific. Recent clinical observ...

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Veröffentlicht in:	The Journal of biological chemistry 2008-02, Vol.283 (9), p.5452
Hauptverfasser:	Robert A. Domaoal, Moira McMahon, Chloe L. Thio, Christopher M. Bailey, Julian Tirado-Rives, Aleksander Obikhod, Mervi Detorio, Kimberly L. Rapp, Robert F. Siliciano, Raymond F. Schinazi, Karen S. Anderson
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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