Cooperative DNA Binding and Communication across the Dimer Interface in the TREX2 3′ → 5′-Exonuclease

The activity of human TREX2-catalyzed 3′ → 5′-deoxyribonuclease has been analyzed in steady-state and single turnover kinetic assays and in equilibrium DNA binding studies. These kinetic data provide evidence for cooperative DNA binding within TREX2 and for coordinated catalysis between the TR...

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Veröffentlicht in:	The Journal of biological chemistry 2008-08, Vol.283 (31), p.21441
Hauptverfasser:	Fred W. Perrino, Udesh de Silva, Scott Harvey, Edward E. Pryor, Jr, Daniel W. Cole, Thomas Hollis
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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