Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt

Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was hypothesized that these defects are the consequence of impaired integration of amino acid, glucose, and energy metabolis...

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Veröffentlicht in:	The Journal of biological chemistry 2008-06, Vol.283 (25), p.17238
Hauptverfasser:	Changhong Li, Itzhak Nissim, Pan Chen, Carol Buettger, Habiba Najafi, Yevgeny Daikhin, Ilana Nissim, Heather W. Collins, Marc Yudkoff, Charles A. Stanley, Franz M. Matschinsky
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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