Differential Regulation of Basic Helix-Loop-Helix Factors Mash1 and Olig2 by β-Amyloid Accelerates Both Differentiation and Death of Cultured Neural Stem/Progenitor Cells

Despite increased neurogenic differentiation markers in the hippocampal CA1 in Alzheimer disease, neurons are not replaced in CA1 and the neocortex in the disease. β-Amyloid (Aβ) might cause deterioration of the brain microenvironment supporting neurogenesis and the survival of immature neurons. T...

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Veröffentlicht in:	The Journal of biological chemistry 2007-07, Vol.282 (27), p.19700
Hauptverfasser:	Yoko Uchida, Shun-ichirou Nakano, Fujiya Gomi, Hiroshi Takahashi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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