Transient Suppression of Ligand-mediated Activation of Epidermal Growth Factor Receptor by Tumor Necrosis Factor-α through the TAK1-p38 Signaling Pathway

Epidermal growth factor receptor (EGFR) has been shown to be activated by specific ligands as well as other cellular stimuli including tumor necrosis factor-α (TNF-α). In the present study, we found that cellular stress suppressed ligand-mediated EGFR activity. Both TNF-α and osmotic stress rapid...

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Veröffentlicht in:	The Journal of biological chemistry 2007-04, Vol.282 (17), p.12698
Hauptverfasser:	Pattama Singhirunnusorn, Yoko Ueno, Mitsuhiro Matsuo, Shunsuke Suzuki, Ikuo Saiki, Hiroaki Sakurai
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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