TrkA Receptor Activation by Nerve Growth Factor Induces Shedding of the p75 Neurotrophin Receptor Followed by Endosomal γ-Secretase-mediated Release of the p75 Intracellular Domain

Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified as a new substrate for γ-secretase-mediated intramembrane proteolysis, ge...

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Veröffentlicht in:	The Journal of biological chemistry 2007-03, Vol.282 (10), p.7606
Hauptverfasser:	Soledad Urra, Claudia A. Escudero, Patricio Ramos, Fernanda Lisbona, Edgardo Allende, Paulina Covarrubias, Jose I. Parraguez, Niccolo Zampieri, Moses V. Chao, Wim Annaert, Francisca C. Bronfman
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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