Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2

Transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase has been shown to be activated by cellular stresses including tumor necrosis factor-α (TNF-α). Here, we characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing...

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Veröffentlicht in:The Journal of biological chemistry 2005-02, Vol.280 (8), p.7359
Hauptverfasser: Pattama Singhirunnusorn, Shunsuke Suzuki, Noritaka Kawasaki, Ikuo Saiki, Hiroaki Sakurai
Format: Artikel
Sprache:eng
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