Heterotrimeric G-protein α-Subunit Adopts a “Preactivated” Conformation When Associated with βγ-Subunits

Activation of a heterotrimeric G-protein by an agonist-stimulated G-protein-coupled receptor requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein. To probe the molecular basis of this signaling process, we are ap...

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Veröffentlicht in:The Journal of biological chemistry 2005-11, Vol.280 (45), p.38071
Hauptverfasser: Najmoutin G. Abdulaev, Tony Ngo, Cheng Zhang, Andy Dinh, Danielle M. Brabazon, Kevin D. Ridge, John P. Marino
Format: Artikel
Sprache:eng
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