Down-regulation of p27Kip1 Promotes Cell Proliferation of Rat Neonatal Cardiomyocytes Induced by Nuclear Expression of Cyclin D1 and CDK4

Mammalian cardiomyocytes lose their capacity to proliferate during terminal differentiation. We have previously reported that the expression of nuclear localization signal-tagged cyclin D1 (D1NLS) and its partner cyclin-dependent kinase 4 (CDK4) induces proliferation of rat neonatal cardiomyocytes....

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (48), p.50429-50436
Hauptverfasser:	Tamamori-Adachi, Mimi, Hayashida, Kentaro, Nobori, Kiyoshi, Omizu, Chie, Yamada, Kazuhiko, Sakamoto, Naoya, Kamura, Takumi, Fukuda, Keiichi, Ogawa, Satoshi, Nakayama, Keiichi I., Kitajima, Shigetaka
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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