A Structural Basis for the Inhibition of the NS5 Dengue Virus mRNA 2′-O-Methyltransferase Domain by Ribavirin 5′-Triphosphate

Ribavirin is one of the few nucleoside analogues currently used in the clinic to treat RNA virus infections, but its mechanism of action remains poorly understood at the molecular level. Here, we show that ribavirin 5′-triphosphate inhibits the activity of the dengue virus 2′- O -methyltransfera...

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Veröffentlicht in:	The Journal of biological chemistry 2004-08, Vol.279 (34), p.35638
Hauptverfasser:	Delphine Benarroch, Marie-Pierre Egloff, Laurence Mulard, Catherine Guerreiro, Jean-Louis Romette, Bruno Canard
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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