Preferential Cu2+ Coordination by His96 and His111 Induces β-Sheet Formation in the Unstructured Amyloidogenic Region of the Prion Protein

The prion protein (PrP) is a Cu 2+ binding cell surface glycoprotein that can misfold into a β-sheet-rich conformation to cause prion diseases. The majority of copper binding studies have concentrated on the octarepeat region of PrP. However, using a range of spectroscopic techniques, we show that...

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Veröffentlicht in:	The Journal of biological chemistry 2004-07, Vol.279 (31), p.32018
Hauptverfasser:	Christopher E. Jones, Salama R. Abdelraheim, David R. Brown, John H. Viles
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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