Sp1 and Sp3 Transcription Factors Mediate Interleukin-1β Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes

Interleukin-1β (IL-1β) is a pleiotropic cytokine that was shown to inhibit the biosynthesis of articular cartilage components. Here we demonstrate that IL-1β inhibits the production of newly synthesized collagens in proliferating rabbit articular chondrocytes and that this effect is accompanied b...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (41), p.39762
Hauptverfasser:	Christos Chadjichristos, Chafik Ghayor, Magdalini Kypriotou, Grégoire Martin, Emmanuelle Renard, Leena Ala-Kokko, Gunthram Suske, Benoit de Crombrugghe, Jean-Pierre Pujol, Philippe Galéra
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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