Alzheimer β-Amyloid Homodimers Facilitate Aβ Fibrillization and the Generation of Conformational Antibodies

We reported previously that stabilized β-amyloid peptide dimers were derived from mutant amyloid precursor protein with a single cysteine in the ectodomain juxtamembrane position. In vivo studies revealed that two forms of SDS-stable Aβ homodimers exist, species ending at Aβ40 and Aβ42. The phen...

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Veröffentlicht in:	The Journal of biological chemistry 2003-09, Vol.278 (37), p.35317
Hauptverfasser:	Ariane Schmechel, Hanswalter Zentgraf, Stefan Scheuermann, Guenter Fritz, Rüdiger Pipkorn, Jennifer Reed, Konrad Beyreuther, Thomas A. Bayer, Gerd Multhaup
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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