Platelet-derived Growth Factor Induces the β-γ-Secretase-mediated Cleavage of Alzheimer's Amyloid Precursor Protein through a Src-Rac-dependent Pathway

The β-amyloid peptide (Aβ) present in the senile plaques of Alzheimer's disease derives from the cleavage of a membrane protein, named APP, driven by two enzymes, known as β- and γ-secretases. The mechanisms regulating this cleavage are not understood. We have developed an experimental syst...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (11), p.9290
Hauptverfasser:	Davide Gianni, Nicola Zambrano, Marida Bimonte, Giuseppina Minopoli, Luc Mercken, Fabio Talamo, Andrea Scaloni, Tommaso Russo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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