Acetylation of the Adenovirus-transforming Protein E1A Determines Nuclear Localization by Disrupting Association with Importin-Î

Posttranslational modifications may alter the biochemical functions of a protein by modifying associations with other macromolecules, allosterically altering intrinsic catalytic activities, or determining subcellular localization. The adenovirus-transforming protein E1A is acetylated by its cellular...

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Veröffentlicht in:The Journal of biological chemistry 2002-10, Vol.277 (41), p.38755
Hauptverfasser: Dana L. Madison, Peter Yaciuk, Roland P. S. Kwok, James R. Lundblad
Format: Artikel
Sprache:eng
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