A Small Molecule Ubiquitination Inhibitor Blocks NF-κB-dependent Cytokine Expression in Cells and Rats

A small molecule inhibitor of NF-κB-dependent cytokine expression was discovered that blocked tumor necrosis factor (TNF) α-induced IκBα degradation in MM6 cells but not the degradation of β-catenin in Jurkat cells. Ro106-9920 blocked lipopolysaccharide (LPS)-dependent expression of TNFα, inte...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2002-06, Vol.277 (26), p.23573
Hauptverfasser:	David C. Swinney, Yi-Zheng Xu, Liliana E. Scarafia, Ina Lee, Amy Y. Mak, Qing-Fen Gan, Chakkodabylu S. Ramesha, Mary A. Mulkins, Jim Dunn, On-Yee So, Teresa Biegel, Marie Dinh, Pamela Volkel, Jim Barnett, Stacie A. Dalrymple, Simon Lee, Martin Huber
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!