The Ducky Mutation in Cacna2d2 Results in Altered Purkinje Cell Morphology and Is Associated with the Expression of a Truncated α2δ-2 Protein with Abnormal Function

The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave seizures and cerebellar ataxia. A mutation in Cacna2d2 , the gene encoding the α2δ-2 voltage-dependent calcium channel accessory subunit, has been found to underlie the ducky phenotype. The α2δ-2 mRNA is strongl...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (10), p.7684
Hauptverfasser:	Jens Brodbeck, Anthony Davies, Jo-Maree Courtney, Alon Meir, Nuria Balaguero, Carles Canti, Fraser J. Moss, Karen M. Page, Wendy S. Pratt, Steven P. Hunt, Jane Barclay, Michele Rees, Annette C. Dolphin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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