Dimers of β2-Glycoprotein I Mimic thein Vitro Effects of β2-Glycoprotein I-Anti-β2-glycoprotein I Antibody Complexes

Anti-β 2 -glycoprotein I antibodies are thought to cause lupus anticoagulant activity by forming bivalent complexes with β 2 -glycoprotein I (β 2 GPI). To test this hypothesis, chimeric fusion proteins were constructed of the dimerization domain (apple 4) of factor XI and β 2 GPI. Both a covalen...

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Veröffentlicht in:	The Journal of biological chemistry 2001-02, Vol.276 (5), p.3060
Hauptverfasser:	Bianca C. H. Lutters, Joost C. M. Meijers, Ronald H. W. M. Derksen, Jef Arnout, Philip G. de Groot
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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