Reactivation of Peroxisome Proliferator-activated Receptor α Is Associated with Contractile Dysfunction in Hypertrophied Rat Heart

In pressure overload-induced hypertrophy, the heart increases its reliance on glucose as a fuel while decreasing fatty acid oxidation. A key regulator of this substrate switching in the hypertrophied heart is peroxisome proliferator-activated receptor α (PPARα). We tested the hypothesis that down-...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (48), p.44390
Hauptverfasser:	Martin E. Young, Frank A. Laws, Gary W. Goodwin, Heinrich Taegtmeyer
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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