A Novel Acetyltransferase Found in Saccharomyces cerevisiae Σ1278b That Detoxifies a Proline Analogue, Azetidine-2-carboxylic Acid

l -Azetidine-2-carboxylic acid (AZC), a toxic four-membered ring analogue of l -proline, is transported into the cells via proline transporters. It causes misfolding of the proteins into which it is incorporated competitively with l -proline and thereby inhibits the growth of the cells. We recently...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (45), p.41998
Hauptverfasser:	Mika Shichiri, Chikara Hoshikawa, Shigeru Nakamori, Hiroshi Takagi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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