Accurate in Vitro End Joining of a DNA Double Strand Break with Partially Cohesive 3′-Overhangs and 3′-Phosphoglycolate Termini

To examine determinants of fidelity in DNA end joining, a substrate containing a model of a staggered free radical-mediated double-strand break, with cohesive phosphoglycolate-terminated 3′-overhangs and a one-base gap in each strand, was constructed. In extracts of Xenopus eggs, human lymphoblast...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (26), p.24323
Hauptverfasser:	Shuang Chen, Kedar V. Inamdar, Petra Pfeiffer, Elke Feldmann, Michele F. Hannah, Yin Yu, Jae-Wan Lee, Tong Zhou, Susan P. Lees-Miller, Lawrence F. Povirk
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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