Aggretin, a Heterodimeric C-type Lectin from Calloselasma rhodostoma (Malayan Pit Viper), Stimulates Platelets by Binding to α2β1 Integrin and Glycoprotein Ib, Activating Syk and Phospholipase Cγ2, but Does Not Involve the Glycoprotein VI/Fc Receptor γ Chain Collagen Receptor

Aggretin, a potent platelet activator, was isolated from Calloselasma rhodostoma venom, and 30-amino acid N-terminal sequences of both subunits were determined. Aggretin belongs to the heterodimeric snake C-type lectin family and is thought to activate platelets by binding to platelet glycoprotein Î...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (24), p.20882
Hauptverfasser:	Alexei Navdaev, Jeannine M. Clemetson, János Polgár, Beate E. Kehrel, Martin Glauner, Edith Magnenat, Timothy N. C. Wells, Kenneth J. Clemetson
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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