Pro-adhesive and Chemotactic Activities of Thrombospondin-1 for Breast Carcinoma Cells Are Mediated by α3β1 Integrin and Regulated by Insulin-like Growth Factor-1 and CD98

Thrombospondin-1 (TSP1) is a matricellular protein that displays both pro- and anti-adhesive activities. Binding to sulfated glycoconjugates mediates most high affinity binding of soluble TSP1 to MDA-MB-435 cells, but attachment and spreading of these cells on immobilized TSP1 is primarily β 1 inte...

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Veröffentlicht in:	The Journal of biological chemistry 1999-04, Vol.274 (16), p.11408
Hauptverfasser:	Subramaniam Chandrasekaran, Neng-hua Guo, Rui G. Rodrigues, James Kaiser, David D. Roberts
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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