c-Myb trans-Activates the Human DNA Topoisomerase IIα Gene Promoter

DNA topoisomerase IIα (topo IIα) is an essential proliferation-dependent nuclear enzyme which has been exploited as an anti-tumor drug target. Since the proliferative status of human leukemia cells is associated with expression of the c- myb proto-oncogene, c-Myb was investigated as a trans -activ...

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Veröffentlicht in:The Journal of biological chemistry 1997-03, Vol.272 (10), p.6278
Hauptverfasser: Tessa L. Brandt, David J. Fraser, Sandra Leal, Pegge M. Halandras, Angela R. Kroll, David J. Kroll
Format: Artikel
Sprache:eng
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