The Alternatively Spliced Kunitz Protease Inhibitor Domain Alters Amyloid β Protein Precursor Processing and Amyloid β Protein Production in Cultured Cells

The insoluble amyloid deposited extracellularly in the brains of patients with Alzheimer's disease (AD) is composed of amyloid β protein, a ∼4-kDa secreted protein that is derived from a set of large proteins collectively referred to as the amyloid β protein precursor (βAPP). During normal...

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Veröffentlicht in:	The Journal of biological chemistry 1996-11, Vol.271 (48), p.30929
Hauptverfasser:	Libin Ho, Ken-ichiro Fukuchi, Steven G. Younkin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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