Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21 Activation

Insulin and epidermal growth factor receptors transmit signals for cell proliferation and gene regulation through formation of active GTP-bound p21 mediated by the guanine nucleotide exchange factor Sos. Sos is constitutively bound to the adaptor protein Grb2 and growth factor stimulation induces as...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 1995-10, Vol.270 (43), p.25320
Hauptverfasser:	W. John Langlois, Toshiyasu Sasaoka, Alan R. Saltiel, Jerrold M. Olefsky
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!