Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

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Veröffentlicht in:	Molecular and Cellular Biology 2004-03, Vol.24 (6), p.2546-2559
Hauptverfasser:	Frederick, Joshua P., Liberati, Nicole T., Waddell, David S., Shi, Yigong, Wang, Xiao-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites - genetics c-myc gene Cell Cycle Proteins Cell Growth and Development Cell Line DNA - genetics DNA - metabolism DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E2F Transcription Factors E2F4 Transcription Factor Genes, myc - drug effects Humans Mice Mice, Knockout Mutagenesis Promoter Regions, Genetic Proto-Oncogene Mas Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Smad3 Protein Smad4 protein Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - metabolism Transforming Growth Factor beta - pharmacology
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