Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

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Veröffentlicht in:	Molecular and Cellular Biology 2002-04, Vol.22 (7), p.2318-2328
Hauptverfasser:	Roberts, Catherine, Sutherland, Helen F., Farmer, Hannah, Kimber, Wendy, Halford, Stephanie, Carey, Alisoun, Brickman, Joshua M., Wynshaw-Boris, Anthony, Scambler, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Body Patterning - genetics Cell Cycle Proteins Congenital Abnormalities - genetics Congenital Abnormalities - pathology Embryo Loss - genetics Embryonic and Fetal Development - genetics Gastrula - metabolism Gastrula - pathology Gene Deletion Genes, Essential - genetics hir1 protein hir2 protein Hira gene Histone Chaperones Homozygote Immunohistochemistry In Situ Hybridization Mammalian Genetic Models with Minimal or Complex Phenotypes Mesoderm - metabolism Mesoderm - pathology Mice Mutagenesis, Site-Directed - genetics Nervous System - embryology Nervous System - metabolism Nervous System - pathology Nuclear Proteins - deficiency Nuclear Proteins - genetics Phenotype Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - deficiency Transcription Factors - genetics
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