CA-074Me Protection against Anthrax Lethal Toxin

Anthrax lethal toxin (LT) activates the NLRP1b (NALP1b) inflammasome and caspase-1 in macrophages from certain inbred mouse strains, but the mechanism by which this occurs is poorly understood. We report here that similar to several NLRP3 (NALP3, cryopyrin)-activating stimuli, LT activation of the N...

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Veröffentlicht in:	Infection and Immunity 2009-10, Vol.77 (10), p.4327-4336
Hauptverfasser:	Newman, Zachary L, Leppla, Stephen H, Moayeri, Mahtab
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Anthrax - prevention & control Antigens, Bacterial Apoptosis Regulatory Proteins - metabolism Bacterial Toxins - antagonists & inhibitors Bacteriology Biological and medical sciences Caspase 1 - metabolism Cathepsin B - antagonists & inhibitors Cathepsin B - metabolism Cell Death Cell Line Cell Survival - drug effects Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Dipeptides - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Intracellular Membranes - drug effects Lysosomes - metabolism Macrophages - drug effects Mice Mice, Inbred BALB C Microbiology Miscellaneous Permeability - drug effects
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