Surfactant Protein A2 (SP-A2) Variants Expressed in CHO Cells Stimulate Phagocytosis of Pseudomonas aeruginosa More than Do SP-A1 Variants

Surfactant protein A (SP-A) enhances phagocytosis of Pseudomonas aeruginosa. Two functional genes, SP-A1 and SP-A2, encode human SP-A. As we showed before, baculovirus-mediated insect cell-expressed SP-A2 enhances the association of P. aeruginosa with rat alveolar macrophages (rAMs) more than does S...

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Veröffentlicht in:	Infection and Immunity 2007-03, Vol.75 (3), p.1403-1412
Hauptverfasser:	Mikerov, Anatoly N, Wang, Guirong, Umstead, Todd M, Zacharatos, Mario, Thomas, Neal J, Phelps, David S, Floros, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Cells, Cultured CHO Cells Cricetinae Cricetulus Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male Microbiology Miscellaneous Phagocytosis - genetics Phagocytosis - immunology Protein Processing, Post-Translational Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pulmonary Surfactant-Associated Protein A - biosynthesis Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein A - physiology Rats Rats, Sprague-Dawley
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