Local and systemic immune responses in murine Helicobacter felis active chronic gastritis
Helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infi...
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| Veröffentlicht in: | Infection and Immunity 1993-06, Vol.61 (6), p.2309-2315 |
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| creator | Fox, J.G Blanco, M Murphy, J.C Taylor, N.S Lee, A Kabok, Z Pappo, J |
| description | Helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. Immunohistochemical analyses of gastric mucosa from H. felis-infected mice revealed the presence of mucosal B220+ cells coalescing into lymphoid follicles surrounded by aggregates of Thy-1.2+ T cells; CD4+, CD5+, and alpha beta T cells predominated in organized gastric mucosal and submucosal lymphoid tissue, and CD11b+ cells occurred frequently in the mucosa. Follicular B cells comprised immunoglobulin M+ (IgM+) and IgA+ cells. Numerous IgA-producing B cells were present in the gastric glands, the lamina propria, and gastric epithelium. Infected animals developed anti-H. felis serum IgM antibody responses up to 8 weeks postinfection and significant levels of IgG anti-H. felis antibody in serum, which remained elevated throughout the 50-week course of the study |
| doi_str_mv | 10.1128/iai.61.6.2309-2315.1993 |
| format | Article |
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Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. Immunohistochemical analyses of gastric mucosa from H. felis-infected mice revealed the presence of mucosal B220+ cells coalescing into lymphoid follicles surrounded by aggregates of Thy-1.2+ T cells; CD4+, CD5+, and alpha beta T cells predominated in organized gastric mucosal and submucosal lymphoid tissue, and CD11b+ cells occurred frequently in the mucosa. Follicular B cells comprised immunoglobulin M+ (IgM+) and IgA+ cells. Numerous IgA-producing B cells were present in the gastric glands, the lamina propria, and gastric epithelium. Infected animals developed anti-H. felis serum IgM antibody responses up to 8 weeks postinfection and significant levels of IgG anti-H. felis antibody in serum, which remained elevated throughout the 50-week course of the study</description><identifier>ISSN: 0019-9567</identifier><identifier>EISSN: 1098-5522</identifier><identifier>DOI: 10.1128/iai.61.6.2309-2315.1993</identifier><identifier>PMID: 8500873</identifier><identifier>CODEN: INFIBR</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animals ; Antibodies, Bacterial - biosynthesis ; Bacterial diseases ; Biological and medical sciences ; CAMPYLOBACTER ; Chronic Disease ; Experimental bacterial diseases and models ; Female ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; Gastritis - immunology ; Gastritis - pathology ; Helicobacter felis ; Helicobacter Infections - immunology ; Helicobacter Infections - pathology ; Immunoglobulin G - biosynthesis ; Immunoglobulin M - biosynthesis ; Immunohistochemistry ; Infectious diseases ; Lymphocyte Subsets - immunology ; Medical sciences ; Mice ; RATON ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA ; SOURIS</subject><ispartof>Infection and Immunity, 1993-06, Vol.61 (6), p.2309-2315</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-c14603cf53b4acf60589afc74847057a584f3640293963a5563e51d01ec1e0863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC280850/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC280850/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4850494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8500873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, J.G</creatorcontrib><creatorcontrib>Blanco, M</creatorcontrib><creatorcontrib>Murphy, J.C</creatorcontrib><creatorcontrib>Taylor, N.S</creatorcontrib><creatorcontrib>Lee, A</creatorcontrib><creatorcontrib>Kabok, Z</creatorcontrib><creatorcontrib>Pappo, J</creatorcontrib><title>Local and systemic immune responses in murine Helicobacter felis active chronic gastritis</title><title>Infection and Immunity</title><addtitle>Infect Immun</addtitle><description>Helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. Immunohistochemical analyses of gastric mucosa from H. felis-infected mice revealed the presence of mucosal B220+ cells coalescing into lymphoid follicles surrounded by aggregates of Thy-1.2+ T cells; CD4+, CD5+, and alpha beta T cells predominated in organized gastric mucosal and submucosal lymphoid tissue, and CD11b+ cells occurred frequently in the mucosa. Follicular B cells comprised immunoglobulin M+ (IgM+) and IgA+ cells. Numerous IgA-producing B cells were present in the gastric glands, the lamina propria, and gastric epithelium. Infected animals developed anti-H. felis serum IgM antibody responses up to 8 weeks postinfection and significant levels of IgG anti-H. felis antibody in serum, which remained elevated throughout the 50-week course of the study</description><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>CAMPYLOBACTER</subject><subject>Chronic Disease</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - immunology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter felis</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter Infections - pathology</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunohistochemistry</subject><subject>Infectious diseases</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>RATON</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><subject>SOURIS</subject><issn>0019-9567</issn><issn>1098-5522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEURi0EKmnhDyAhBgmxm-D3Y8ECVZQiRWIBXbCybhxPYjQzDr4zRf33OEoU0RUrP-75rh-HkDeMLhnj9kOCtNRsqZdcUNdywdSSOSeekAWjzrZKcf6ULChlrnVKm-fkEvFXXUop7QW5sIpSa8SC_FzlAH0D46bBB5zikEKThmEeY1Mi7vOIEZs0NsNcUt27jX0KeQ1hiqXp6gKbOk_3sQm7ksca3gJOJU0JX5BnHfQYX57GK3J38_nH9W27-vbl6_WnVRu00FMbmNRUhE6JtYTQaaqsgy4YaaWhyoCyshNaUu6E0wKU0iIqtqEsBhap1eKKfDz23c_rIW5CHKcCvd-XNEB58BmSf1wZ085v873nltZvqPn3p3zJv-eIkx8Shtj3MMY8ozfKKMuF-C_ItKGUCldBcwRDyYgldufLMOoP9ny15zXz2h_s-YM9f7BXk6__fcs5d9JV6-9OdcCqrSswhoRnTFZOOlmxt0dsl7a7P6lEDzg8PrQyr45MB9nDttQ2d9-d5NwZLv4CNTW3zA</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Fox, J.G</creator><creator>Blanco, M</creator><creator>Murphy, J.C</creator><creator>Taylor, N.S</creator><creator>Lee, A</creator><creator>Kabok, Z</creator><creator>Pappo, J</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930601</creationdate><title>Local and systemic immune responses in murine Helicobacter felis active chronic gastritis</title><author>Fox, J.G ; Blanco, M ; Murphy, J.C ; Taylor, N.S ; Lee, A ; Kabok, Z ; Pappo, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-c14603cf53b4acf60589afc74847057a584f3640293963a5563e51d01ec1e0863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>CAMPYLOBACTER</topic><topic>Chronic Disease</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Gastric Mucosa - microbiology</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - immunology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter felis</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter Infections - pathology</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunohistochemistry</topic><topic>Infectious diseases</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>RATON</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><topic>SOURIS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, J.G</creatorcontrib><creatorcontrib>Blanco, M</creatorcontrib><creatorcontrib>Murphy, J.C</creatorcontrib><creatorcontrib>Taylor, N.S</creatorcontrib><creatorcontrib>Lee, A</creatorcontrib><creatorcontrib>Kabok, Z</creatorcontrib><creatorcontrib>Pappo, J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and Immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, J.G</au><au>Blanco, M</au><au>Murphy, J.C</au><au>Taylor, N.S</au><au>Lee, A</au><au>Kabok, Z</au><au>Pappo, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local and systemic immune responses in murine Helicobacter felis active chronic gastritis</atitle><jtitle>Infection and Immunity</jtitle><addtitle>Infect Immun</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>61</volume><issue>6</issue><spage>2309</spage><epage>2315</epage><pages>2309-2315</pages><issn>0019-9567</issn><eissn>1098-5522</eissn><coden>INFIBR</coden><abstract>Helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. Immunohistochemical analyses of gastric mucosa from H. felis-infected mice revealed the presence of mucosal B220+ cells coalescing into lymphoid follicles surrounded by aggregates of Thy-1.2+ T cells; CD4+, CD5+, and alpha beta T cells predominated in organized gastric mucosal and submucosal lymphoid tissue, and CD11b+ cells occurred frequently in the mucosa. Follicular B cells comprised immunoglobulin M+ (IgM+) and IgA+ cells. Numerous IgA-producing B cells were present in the gastric glands, the lamina propria, and gastric epithelium. 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| source | American Society for Microbiology; MEDLINE; PMC (PubMed Central); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Bacterial - biosynthesis Bacterial diseases Biological and medical sciences CAMPYLOBACTER Chronic Disease Experimental bacterial diseases and models Female Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastritis - immunology Gastritis - pathology Helicobacter felis Helicobacter Infections - immunology Helicobacter Infections - pathology Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Immunohistochemistry Infectious diseases Lymphocyte Subsets - immunology Medical sciences Mice RATON REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA SOURIS |
| title | Local and systemic immune responses in murine Helicobacter felis active chronic gastritis |
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