Indomethacin promotes differentiation of Trypanosoma brucei

Trypanosoma brucei, treatment of mice with indomethacin (prostaglandin inhibitor) lowered parasitemia because it quickly promoted differentiation of rapidly dividing long slender trypanosomes into short stumpy forms that do not divide in the mammal

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Bibliographische Detailangaben
Veröffentlicht in:	Infection and Immunity 1984, Vol.43 (1), p.445-448
Hauptverfasser:	Jack, R.M, Black, S.J, Reed, S.L, Davis, C.E
Format:	Artikel
Sprache:	eng
Schlagworte:	animal development Animals Biological and medical sciences Cell Differentiation - drug effects Experimental protozoal diseases and models Human protozoal diseases Indomethacin - pharmacology Infectious diseases Kinetics Male Medical sciences Mice Mice, Inbred C57BL Parasitic diseases prostaglandins Protozoa Protozoal diseases Tropical medicine Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - physiology Trypanosomiasis
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Beschreibung
Zusammenfassung:	Trypanosoma brucei, treatment of mice with indomethacin (prostaglandin inhibitor) lowered parasitemia because it quickly promoted differentiation of rapidly dividing long slender trypanosomes into short stumpy forms that do not divide in the mammal
ISSN:	0019-9567 1098-5522
DOI:	10.1128/iai.43.1.445-448.1984