Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152
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Veröffentlicht in: | Applied and Environmental Microbiology 2011-11, Vol.77 (22), p.8034-8040 |
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creator | FEWER, David P OSTERHOLM, Julia ROUHIAINEN, Leo JOKELA, Jouni WAHLSTEN, Matti SIVONEN, Kaarina |
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</description><identifier>ISSN: 0099-2240</identifier><identifier>EISSN: 1098-5336</identifier><identifier>DOI: 10.1128/AEM.05993-11</identifier><identifier>PMID: 21948844</identifier><identifier>CODEN: AEMIDF</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>active sites ; Bacteria ; Bacterial Toxins - biosynthesis ; Biological and medical sciences ; Biosynthesis ; Biosynthetic Pathways - genetics ; carbon ; Cluster Analysis ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; drugs ; Fundamental and applied biological sciences. Psychology ; Gene Fusion ; Genes ; Genes, Bacterial ; Genetics and Molecular Biology ; hybrids ; Microbiology ; Molecular Sequence Data ; Multigene Family ; Nostoc ; Nostoc - enzymology ; Nostoc - metabolism ; open reading frames ; Peptide Synthases - genetics ; Peptide Synthases - metabolism ; Peptides ; Peptides, Cyclic - biosynthesis ; Phylogenetics ; Phylogeny ; Polyketide Synthases - genetics ; Polyketide Synthases - metabolism ; proteins ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; substrate specificity ; toxicity</subject><ispartof>Applied and Environmental Microbiology, 2011-11, Vol.77 (22), p.8034-8040</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Microbiology Nov 2011</rights><rights>Copyright © 2011, American Society for Microbiology. All Rights Reserved. 2011 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-d8fd30e1a161a971fd9b35bb4561a638065bfe3838fcbc94a95986a9db2cefaa3</citedby><cites>FETCH-LOGICAL-c566t-d8fd30e1a161a971fd9b35bb4561a638065bfe3838fcbc94a95986a9db2cefaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208980/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208980/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,3175,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24771103$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21948844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FEWER, David P</creatorcontrib><creatorcontrib>OSTERHOLM, Julia</creatorcontrib><creatorcontrib>ROUHIAINEN, Leo</creatorcontrib><creatorcontrib>JOKELA, Jouni</creatorcontrib><creatorcontrib>WAHLSTEN, Matti</creatorcontrib><creatorcontrib>SIVONEN, Kaarina</creatorcontrib><title>Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152</title><title>Applied and Environmental Microbiology</title><addtitle>Appl Environ Microbiol</addtitle><description>Classifications
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</description><subject>active sites</subject><subject>Bacteria</subject><subject>Bacterial Toxins - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Biosynthetic Pathways - genetics</subject><subject>carbon</subject><subject>Cluster Analysis</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>drugs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Fusion</subject><subject>Genes</subject><subject>Genes, Bacterial</subject><subject>Genetics and Molecular Biology</subject><subject>hybrids</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Nostoc</subject><subject>Nostoc - enzymology</subject><subject>Nostoc - metabolism</subject><subject>open reading frames</subject><subject>Peptide Synthases - genetics</subject><subject>Peptide Synthases - metabolism</subject><subject>Peptides</subject><subject>Peptides, Cyclic - biosynthesis</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Polyketide Synthases - genetics</subject><subject>Polyketide Synthases - metabolism</subject><subject>proteins</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>substrate specificity</subject><subject>toxicity</subject><issn>0099-2240</issn><issn>1098-5336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFv1DAQhS0EokvhxhlZSEgcyGLHiWNfKpWl0EqlVGo5W2PHaVySONgJkD_C78Vtly5wmhm9T09v9BB6Tsma0ly8PTz6tCallCyj9AFaUSJFVjLGH6IVIVJmeV6QPfQkxmtCSEG4eIz2cioLIYpihX6d-Tj5sV2MG_A75-MyTK2NLuKTiN-7YM1ka6wXDPh40cHV-Nx3y1c7udriixsYos3O_BCc9tH30OFzO-5UOyUdJ--04kv_0xm8WWDwGpJxcHOPbwMYHMc1vpgCJJSW-VP0qIEu2mfbuY--fDi63Bxnp58_nmwOTzNTcj5ltWhqRiwFyinIija11KzUuijTzZkgvNSNZYKJxmgjC5ClFBxkrXNjGwC2jw7ufMdZ97Y2dkgROjUG10NYlAen_lUG16or_12xnAgpSDJ4vTUI_tts46R6F43tOhisn6OijItSUCFkQl_-h177OQzpPSUJ41JKXiTozR1kgo8x2OY-CyXqpm-V-la3facz4S_-zn8P_yk4Aa-2AEQDXRNgMC7uuKKqKCVsF651V-2P1LuC2CuwvaoqlecqvVqw33FqwUE</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>FEWER, David P</creator><creator>OSTERHOLM, Julia</creator><creator>ROUHIAINEN, Leo</creator><creator>JOKELA, Jouni</creator><creator>WAHLSTEN, Matti</creator><creator>SIVONEN, Kaarina</creator><general>American Society for Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. 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Psychology</topic><topic>Gene Fusion</topic><topic>Genes</topic><topic>Genes, Bacterial</topic><topic>Genetics and Molecular Biology</topic><topic>hybrids</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Nostoc</topic><topic>Nostoc - enzymology</topic><topic>Nostoc - metabolism</topic><topic>open reading frames</topic><topic>Peptide Synthases - genetics</topic><topic>Peptide Synthases - metabolism</topic><topic>Peptides</topic><topic>Peptides, Cyclic - biosynthesis</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Polyketide Synthases - genetics</topic><topic>Polyketide Synthases - metabolism</topic><topic>proteins</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>substrate specificity</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FEWER, David P</creatorcontrib><creatorcontrib>OSTERHOLM, Julia</creatorcontrib><creatorcontrib>ROUHIAINEN, Leo</creatorcontrib><creatorcontrib>JOKELA, Jouni</creatorcontrib><creatorcontrib>WAHLSTEN, Matti</creatorcontrib><creatorcontrib>SIVONEN, Kaarina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Applied and Environmental Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FEWER, David P</au><au>OSTERHOLM, Julia</au><au>ROUHIAINEN, Leo</au><au>JOKELA, Jouni</au><au>WAHLSTEN, Matti</au><au>SIVONEN, Kaarina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>21948844</pmid><doi>10.1128/AEM.05993-11</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | active sites Bacteria Bacterial Toxins - biosynthesis Biological and medical sciences Biosynthesis Biosynthetic Pathways - genetics carbon Cluster Analysis DNA, Bacterial - chemistry DNA, Bacterial - genetics drugs Fundamental and applied biological sciences. Psychology Gene Fusion Genes Genes, Bacterial Genetics and Molecular Biology hybrids Microbiology Molecular Sequence Data Multigene Family Nostoc Nostoc - enzymology Nostoc - metabolism open reading frames Peptide Synthases - genetics Peptide Synthases - metabolism Peptides Peptides, Cyclic - biosynthesis Phylogenetics Phylogeny Polyketide Synthases - genetics Polyketide Synthases - metabolism proteins Sequence Analysis, DNA Sequence Homology, Amino Acid substrate specificity toxicity |
title | Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152 |
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