Identification of DysI, the Immunity Factor of the Streptococcal Bacteriocin Dysgalacticin

DysI is identified as the protein that confers specific immunity to dysgalacticin, a plasmid-encoded streptococcal bacteriocin. dysI is transcribed as part of the copG-repB-dysI replication-associated operon. DysI appears to function at the membrane level to prevent the inhibitory effects of dysgala...

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Veröffentlicht in:	Applied and Environmental Microbiology 2010-12, Vol.76 (23), p.7885-7889
Hauptverfasser:	Swe, Pearl M, Heng, Nicholas C.K, Cook, Gregory M, Tagg, John R, Jack, Ralph W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - antagonists & inhibitors Anti-Bacterial Agents - pharmacology ATP Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriocins - antagonists & inhibitors Bacteriocins - biosynthesis Bacteriocins - genetics Bacteriocins - pharmacology Bacteriology Genes, Bacterial Genetics and Molecular Biology Glucose Gram-positive bacteria Membranes Microbial Sensitivity Tests Molecular Sequence Data Operon Plasmids Proteins Streptococcus Streptococcus - drug effects Streptococcus - genetics Streptococcus - metabolism Transcription, Genetic
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Zusammenfassung:	DysI is identified as the protein that confers specific immunity to dysgalacticin, a plasmid-encoded streptococcal bacteriocin. dysI is transcribed as part of the copG-repB-dysI replication-associated operon. DysI appears to function at the membrane level to prevent the inhibitory effects of dysgalacticin on glucose transport, membrane integrity, and intracellular ATP content.
ISSN:	0099-2240 1098-5336 1098-6596
DOI:	10.1128/aem.01707-10