Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2010-09, Vol.54 (9), p.3913-3921 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | Chung, Suhman Wendeler, Michaela Rausch, Jason W Beilhartz, Greg Gotte, Matthias O'Keefe, Barry R Bermingham, Alun Beutler, John A Liu, Shixin Zhuang, Xiaowei Le Grice, Stuart F J |
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| doi_str_mv | 10.1128/aac.00434-10 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>ISSN: 1098-6596</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.00434-10</identifier><identifier>PMID: 20547794</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>amides ; amines ; Anti-HIV Agents ; Anti-HIV Agents - chemistry ; Anti-HIV Agents - pharmacology ; Antiviral Agents ; Catalytic Domain ; Cyclopentane ; Data processing ; DNA biosynthesis ; Enzyme Inhibitors ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; Human immunodeficiency virus 1 ; Human immunodeficiency virus 2 ; Humans ; Hybrids ; Immunodeficiency ; Mimicry ; Models, Molecular ; Molecular modelling ; Molecular Structure ; pharmacophores ; Ribonuclease H ; Ribonuclease H, Human Immunodeficiency Virus ; Ribonuclease H, Human Immunodeficiency Virus - antagonists & inhibitors ; Ribonuclease H, Human Immunodeficiency Virus - chemistry ; RNA-directed DNA polymerase ; Spectroscopy ; Temperature ; Thermodynamics ; Urea</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2010-09, Vol.54 (9), p.3913-3921</ispartof><rights>Copyright © 2010 American Society for Microbiology</rights><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a541t-52142fcea746041b12ee45b6fc95a73988a384c2500101b77bc2b9fee6937b2b3</citedby><cites>FETCH-LOGICAL-a541t-52142fcea746041b12ee45b6fc95a73988a384c2500101b77bc2b9fee6937b2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935023/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935023/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20547794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Suhman</creatorcontrib><creatorcontrib>Wendeler, Michaela</creatorcontrib><creatorcontrib>Rausch, Jason W</creatorcontrib><creatorcontrib>Beilhartz, Greg</creatorcontrib><creatorcontrib>Gotte, Matthias</creatorcontrib><creatorcontrib>O'Keefe, Barry R</creatorcontrib><creatorcontrib>Bermingham, Alun</creatorcontrib><creatorcontrib>Beutler, John A</creatorcontrib><creatorcontrib>Liu, Shixin</creatorcontrib><creatorcontrib>Zhuang, Xiaowei</creatorcontrib><creatorcontrib>Le Grice, Stuart F J</creatorcontrib><title>Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>amides</subject><subject>amines</subject><subject>Anti-HIV Agents</subject><subject>Anti-HIV Agents - chemistry</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Antiviral Agents</subject><subject>Catalytic Domain</subject><subject>Cyclopentane</subject><subject>Data processing</subject><subject>DNA biosynthesis</subject><subject>Enzyme Inhibitors</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human immunodeficiency virus 2</subject><subject>Humans</subject><subject>Hybrids</subject><subject>Immunodeficiency</subject><subject>Mimicry</subject><subject>Models, Molecular</subject><subject>Molecular modelling</subject><subject>Molecular Structure</subject><subject>pharmacophores</subject><subject>Ribonuclease H</subject><subject>Ribonuclease H, Human Immunodeficiency Virus</subject><subject>Ribonuclease H, Human Immunodeficiency Virus - antagonists & inhibitors</subject><subject>Ribonuclease H, Human Immunodeficiency Virus - chemistry</subject><subject>RNA-directed DNA polymerase</subject><subject>Spectroscopy</subject><subject>Temperature</subject><subject>Thermodynamics</subject><subject>Urea</subject><issn>0066-4804</issn><issn>1098-6596</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUx4Modlu9eZbxJIJT83NmcikMS-suFAS1XkOSfbObMpOsyaSy_72xW4sexFPIe598eMk3CL0i-JwQ2n3Q2p5jzBmvCX6CFgTLrm6EbJ6iBcZNU_MO8xN0mtItLnsh8XN0QrHgbSv5Au2_zDHbOUeoezu7Ozcfqt7r8ZBcqsJQfXP-MIZtyKm6iaCrtd854-YQ77urPGlfracp-7CBwVkH3h7KoZhTfeltKW6qz84En-0IOkG1eoGeDXpM8PJhPUM3V5dfl6v6-tPH9bK_rrXgZK4FJZwOFnTLG8yJIRSAC9MMVgrdMtl1mnXcUoExwcS0rbHUyAGgkaw11LAzdHH07rOZYGPBz1GPah_dpONBBe3U3x3vdmob7hSVTGDKiuDtgyCG7xnSrCaXLIyj9lCeQ7WCd7LM0PyfLGBDBO4K-f5I2hhSijA8zkOw-pWm6vuluk-zVAr-7ojrNFF1G3IsyaR_sa__vO-j-HfUBXhzBHZuu_vhIqhiVeX3KMGVVEwSxn4CGyy0LA</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Chung, Suhman</creator><creator>Wendeler, Michaela</creator><creator>Rausch, Jason W</creator><creator>Beilhartz, Greg</creator><creator>Gotte, Matthias</creator><creator>O'Keefe, Barry R</creator><creator>Bermingham, Alun</creator><creator>Beutler, John A</creator><creator>Liu, Shixin</creator><creator>Zhuang, Xiaowei</creator><creator>Le Grice, Stuart F J</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H</title><author>Chung, Suhman ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>20547794</pmid><doi>10.1128/aac.00434-10</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2010-09, Vol.54 (9), p.3913-3921 |
| issn | 0066-4804 1098-6596 1098-6596 |
| language | eng |
| recordid | cdi_highwire_asm_aac_54_9_3913 |
| source | MEDLINE; PubMed Central; EZB Electronic Journals Library |
| subjects | amides amines Anti-HIV Agents Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antiviral Agents Catalytic Domain Cyclopentane Data processing DNA biosynthesis Enzyme Inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans Hybrids Immunodeficiency Mimicry Models, Molecular Molecular modelling Molecular Structure pharmacophores Ribonuclease H Ribonuclease H, Human Immunodeficiency Virus Ribonuclease H, Human Immunodeficiency Virus - antagonists & inhibitors Ribonuclease H, Human Immunodeficiency Virus - chemistry RNA-directed DNA polymerase Spectroscopy Temperature Thermodynamics Urea |
| title | Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H |
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