VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2006-05, Vol.50 (5), p.1813-1822
Hauptverfasser:	KAI LIN, PERNI, Robert B, KWONG, Ann D, CHAO LIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - chemistry Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Binding Sites Biological and medical sciences Carcinoma, Hepatocellular - pathology Cell Culture Techniques Cell Line, Tumor Cell Survival - drug effects Cells, Cultured Dogs Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drug Synergism Hepacivirus Hepacivirus - drug effects Hepacivirus - enzymology Hepatitis C virus Hepatocytes - drug effects Human viral diseases Humans Infectious diseases Inhibitory Concentration 50 Interferon Type I - pharmacology Leukocytes, Mononuclear - drug effects Liver Neoplasms - pathology Medical sciences Molecular Structure Oligopeptides Oligopeptides - chemistry Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Pharmacology. Drug treatments Protease Inhibitors Protease Inhibitors - chemistry Protease Inhibitors - pharmacokinetics Protease Inhibitors - pharmacology Protein Binding Rats Recombinant Proteins Replicon Replicon - drug effects RNA, Viral - physiology Viral diseases Viral hepatitis
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