Cellulitis Revealing a Cryptococcosis‐Related Immune Reconstitution Inflammatory Syndrome in a Renal Allograft Recipient

Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans‐associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94–460/mm3) and required the administration of a short‐term steroid therapy to resolve. This renal transplant recipient developed severe cellulitis in the context of Cryptococcus neoformans‐associated IRIS while undergoing reduction of his immunosuppressive therapy and required the administration of a short‐term steroid therapy to resolve.