3D structures of the Plasmodium vivax subtilisin‐like drug target SUB1 reveal conformational changes to accommodate a substrate‐derived α‐ketoamide inhibitor

The constant selection and propagation of multi‐resistant Plasmodium sp. parasites require the identification of new antimalarial candidates involved in as‐yet untargeted metabolic pathways. Subtilisin‐like protease 1 (SUB1) belongs to a new generation of drug targets because it plays a crucial role...

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