Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study
Summary Background Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. Methods Cross-sectional carriage surveys were done in...
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| Veröffentlicht in: | The Lancet global health 2016-12, Vol.4 (12), p.e989-e995 |
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| creator | Ali, Oumer Aseffa, Abraham Omer, Ahmed Bedru Lema, Tsehaynesh Demissie, Tesfaye Moti Tekletsion, Yenenesh Worku, Alemayehu Xabher, Haimanot Guebre Yamuah, Lawrence Boukary, Rahamatou Moustapha Collard, Jean-Marc Dan Dano, Ibrahim Habiboulaye, Ibrahim Issaka, Bassira Jusot, Jean-François Ousmane, Sani Rabe, Issoufa Dauglaz, Doumagoum Moto Gami, Jean Pierre Gamougam, Kadidja Mbainadji, Lodoum Naibei, Nathan Narbé, Maxime Toralta, Jacques Berthe, Abdoulaye Diallo, Kanny Keita, Mahamadou Coulibaly, Adama Onwuchekwa, Uma Sow, Samba O Tamboura, Boubou Traore, Awa Toure, Aliou Clark, Tom Mayer, Leonard Amodu, Mary Beida, Omeiza Gadzama, Galadima Omotara, Babatunji Zailani, Sambo Yahya, Shuaibu Chandramohan, Daniel Greenwood, Brian M Hassan-King, Musa Manigart, Olivier Nascimento, Maria M Stuart, James Woukeu, Arouna Basta, Nicole E Bai, Xilian Borrow, Ray Findlow, Helen Alavo, Serge Bassene, Hubert Diallo, Aldiouma Dieng, Marietou Doucouré, Souleymane Gomis, Jules François Ndiaye, Assane Sokhna, Cheikh Trape, Jean François Bugri, Akalifa Forgor, Abudulai Hodgson, Abraham Osei, Isaac Quaye, Stephen L Williams, John Wontuo, Peter Irving, Thomas Trotter, Caroline L Karachaliou, Andromachi Bennett, Julia Hill, Dorothea Harrison, Odile Maiden, Martin C Rebbetts, Lisa Watkins, Eleanor |
| description | Summary Background Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. Methods Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study. We took pharyngeal swabs at first visit and took further swabs twice a month for 2 months and then monthly for a further 4 months. We used conventional bacteriological and molecular techniques to identify and characterise meningococci. We estimated the rates of carriage acquisition and recovery using a multi-state Markov model. Findings Meningococci were isolated from 241 (25%) of 980 members of 133 households in which a carrier had been identified in the cross-sectional survey or at the first household visit. Carriage was detected subsequently in another household member who was not an index carrier in 75 households. Transmission within a household, suggested by detection of a further carrier with the same strain as the index carrier, was found in 52 of these 75 households. Children younger than 5 years were the group that most frequently acquired carriage from other household members. The overall individual acquisition rate was 2·4% (95% CI 1·6–4·0) per month, varying by age and household carriage status. The mean duration of carriage was 3·4 months (95% CI 2·7–4·4). Interpretation In the African meningitis belt, transmission of meningococci within households is important, particularly for young children, and periods of carriage are usually of short duration. Funding Bill & Melinda Gates Foundation, Wellcome Trust. |
| doi_str_mv | 10.1016/S2214-109X(16)30244-3 |
| format | Article |
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We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. Methods Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study. We took pharyngeal swabs at first visit and took further swabs twice a month for 2 months and then monthly for a further 4 months. We used conventional bacteriological and molecular techniques to identify and characterise meningococci. We estimated the rates of carriage acquisition and recovery using a multi-state Markov model. Findings Meningococci were isolated from 241 (25%) of 980 members of 133 households in which a carrier had been identified in the cross-sectional survey or at the first household visit. Carriage was detected subsequently in another household member who was not an index carrier in 75 households. Transmission within a household, suggested by detection of a further carrier with the same strain as the index carrier, was found in 52 of these 75 households. Children younger than 5 years were the group that most frequently acquired carriage from other household members. The overall individual acquisition rate was 2·4% (95% CI 1·6–4·0) per month, varying by age and household carriage status. The mean duration of carriage was 3·4 months (95% CI 2·7–4·4). Interpretation In the African meningitis belt, transmission of meningococci within households is important, particularly for young children, and periods of carriage are usually of short duration. Funding Bill & Melinda Gates Foundation, Wellcome Trust.</description><identifier>ISSN: 2214-109X</identifier><identifier>ISSN: 2572-116X</identifier><identifier>EISSN: 2214-109X</identifier><identifier>DOI: 10.1016/S2214-109X(16)30244-3</identifier><identifier>PMID: 27855873</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Africa ; Age Factors ; Bacteriology ; Carrier State ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Family Characteristics ; Female ; Human health and pathology ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Internal Medicine ; Life Sciences ; Longitudinal Studies ; Male ; Meningitis, Meningococcal ; Meningitis, Meningococcal - diagnosis ; Meningitis, Meningococcal - transmission ; Microbiology and Parasitology ; Neisseria meningitidis ; Neisseria meningitidis - isolation & purification ; Santé publique et épidémiologie</subject><ispartof>The Lancet global health, 2016-12, Vol.4 (12), p.e989-e995</ispartof><rights>The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license</rights><rights>2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license</rights><rights>Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-2539d57bceb1508c8de156f9bb19389c9c7779756cb072ca2d9bb838c1350f613</citedby><cites>FETCH-LOGICAL-c505t-2539d57bceb1508c8de156f9bb19389c9c7779756cb072ca2d9bb838c1350f613</cites><orcidid>0000-0002-4487-1874</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27855873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-03238489$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Oumer</creatorcontrib><creatorcontrib>Aseffa, Abraham</creatorcontrib><creatorcontrib>Omer, Ahmed Bedru</creatorcontrib><creatorcontrib>Lema, Tsehaynesh</creatorcontrib><creatorcontrib>Demissie, Tesfaye Moti</creatorcontrib><creatorcontrib>Tekletsion, Yenenesh</creatorcontrib><creatorcontrib>Worku, Alemayehu</creatorcontrib><creatorcontrib>Xabher, Haimanot Guebre</creatorcontrib><creatorcontrib>Yamuah, Lawrence</creatorcontrib><creatorcontrib>Boukary, Rahamatou Moustapha</creatorcontrib><creatorcontrib>Collard, Jean-Marc</creatorcontrib><creatorcontrib>Dan Dano, Ibrahim</creatorcontrib><creatorcontrib>Habiboulaye, Ibrahim</creatorcontrib><creatorcontrib>Issaka, Bassira</creatorcontrib><creatorcontrib>Jusot, Jean-François</creatorcontrib><creatorcontrib>Ousmane, Sani</creatorcontrib><creatorcontrib>Rabe, Issoufa</creatorcontrib><creatorcontrib>Dauglaz, Doumagoum Moto</creatorcontrib><creatorcontrib>Gami, Jean Pierre</creatorcontrib><creatorcontrib>Gamougam, Kadidja</creatorcontrib><creatorcontrib>Mbainadji, Lodoum</creatorcontrib><creatorcontrib>Naibei, Nathan</creatorcontrib><creatorcontrib>Narbé, Maxime</creatorcontrib><creatorcontrib>Toralta, Jacques</creatorcontrib><creatorcontrib>Berthe, Abdoulaye</creatorcontrib><creatorcontrib>Diallo, Kanny</creatorcontrib><creatorcontrib>Keita, Mahamadou</creatorcontrib><creatorcontrib>Coulibaly, Adama</creatorcontrib><creatorcontrib>Onwuchekwa, Uma</creatorcontrib><creatorcontrib>Sow, Samba O</creatorcontrib><creatorcontrib>Tamboura, Boubou</creatorcontrib><creatorcontrib>Traore, Awa</creatorcontrib><creatorcontrib>Toure, Aliou</creatorcontrib><creatorcontrib>Clark, Tom</creatorcontrib><creatorcontrib>Mayer, Leonard</creatorcontrib><creatorcontrib>Amodu, Mary</creatorcontrib><creatorcontrib>Beida, Omeiza</creatorcontrib><creatorcontrib>Gadzama, Galadima</creatorcontrib><creatorcontrib>Omotara, Babatunji</creatorcontrib><creatorcontrib>Zailani, Sambo</creatorcontrib><creatorcontrib>Yahya, Shuaibu</creatorcontrib><creatorcontrib>Chandramohan, Daniel</creatorcontrib><creatorcontrib>Greenwood, Brian M</creatorcontrib><creatorcontrib>Hassan-King, Musa</creatorcontrib><creatorcontrib>Manigart, Olivier</creatorcontrib><creatorcontrib>Nascimento, Maria</creatorcontrib><creatorcontrib>M Stuart, James</creatorcontrib><creatorcontrib>Woukeu, Arouna</creatorcontrib><creatorcontrib>Basta, Nicole E</creatorcontrib><creatorcontrib>Bai, Xilian</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><creatorcontrib>Findlow, Helen</creatorcontrib><creatorcontrib>Alavo, Serge</creatorcontrib><creatorcontrib>Bassene, Hubert</creatorcontrib><creatorcontrib>Diallo, Aldiouma</creatorcontrib><creatorcontrib>Dieng, Marietou</creatorcontrib><creatorcontrib>Doucouré, Souleymane</creatorcontrib><creatorcontrib>Gomis, Jules François</creatorcontrib><creatorcontrib>Ndiaye, Assane</creatorcontrib><creatorcontrib>Sokhna, Cheikh</creatorcontrib><creatorcontrib>Trape, Jean François</creatorcontrib><creatorcontrib>Bugri, Akalifa</creatorcontrib><creatorcontrib>Forgor, Abudulai</creatorcontrib><creatorcontrib>Hodgson, Abraham</creatorcontrib><creatorcontrib>Osei, Isaac</creatorcontrib><creatorcontrib>Quaye, Stephen L</creatorcontrib><creatorcontrib>Williams, John</creatorcontrib><creatorcontrib>Wontuo, Peter</creatorcontrib><creatorcontrib>Irving, Thomas</creatorcontrib><creatorcontrib>Trotter, Caroline L</creatorcontrib><creatorcontrib>Karachaliou, Andromachi</creatorcontrib><creatorcontrib>Bennett, Julia</creatorcontrib><creatorcontrib>Hill, Dorothea</creatorcontrib><creatorcontrib>Harrison, Odile</creatorcontrib><creatorcontrib>Maiden, Martin C</creatorcontrib><creatorcontrib>Rebbetts, Lisa</creatorcontrib><creatorcontrib>Watkins, Eleanor</creatorcontrib><creatorcontrib>MenAfriCar Consortium</creatorcontrib><title>Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study</title><title>The Lancet global health</title><addtitle>Lancet Glob Health</addtitle><description>Summary Background Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. Methods Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study. We took pharyngeal swabs at first visit and took further swabs twice a month for 2 months and then monthly for a further 4 months. We used conventional bacteriological and molecular techniques to identify and characterise meningococci. We estimated the rates of carriage acquisition and recovery using a multi-state Markov model. Findings Meningococci were isolated from 241 (25%) of 980 members of 133 households in which a carrier had been identified in the cross-sectional survey or at the first household visit. Carriage was detected subsequently in another household member who was not an index carrier in 75 households. Transmission within a household, suggested by detection of a further carrier with the same strain as the index carrier, was found in 52 of these 75 households. Children younger than 5 years were the group that most frequently acquired carriage from other household members. The overall individual acquisition rate was 2·4% (95% CI 1·6–4·0) per month, varying by age and household carriage status. The mean duration of carriage was 3·4 months (95% CI 2·7–4·4). Interpretation In the African meningitis belt, transmission of meningococci within households is important, particularly for young children, and periods of carriage are usually of short duration. Funding Bill & Melinda Gates Foundation, Wellcome Trust.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Africa</subject><subject>Age Factors</subject><subject>Bacteriology</subject><subject>Carrier State</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Meningitis, Meningococcal</subject><subject>Meningitis, Meningococcal - diagnosis</subject><subject>Meningitis, Meningococcal - transmission</subject><subject>Microbiology and Parasitology</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - isolation & purification</subject><subject>Santé publique et épidémiologie</subject><issn>2214-109X</issn><issn>2572-116X</issn><issn>2214-109X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQjRCIVqU_AeRjOYT6I45tDqBVBV2kFRwAiZvlOBPWxWsvdlJp_z3OpiyIC754Pt680bxXVc8JfkUwaa8_U0qammD17Yq0LxmmTVOzR9X5qfz4r_isusz5DpenFKNCPK3OqJCcS8HOK7-OU4Zt9D0akwl553J2MaA4oI9QYkjOoB0EF7670fUuIxfQuAW0GpKzJvzpZdSBH18jg3ycC1PvgvHIxm1MI8olPzyrngzGZ7h8-C-qr-_ffblZ15tPtx9uVpvacszHmnKmei46Cx3hWFrZA-HtoLqOKCaVVVYIoQRvbYcFtYb2pSWZtIRxPLSEXVT1wrs1Xu-T25l00NE4vV5t9N7kEaakMaNMNlLdz_irBb9P8ecEedRFBgvemwBFHk1kQ4RqGacFyheoTTHnBMOJn2A9e6OP3uhZeF2yozealbkXDyumbgf9aeq3EwXwdgFAEebeQdLZOggWepfAjrqP7r8r3vzDYL0LxST_Aw6Q7-KUiiHlGp2pxgvJzEHaIwNjvwBysrQj</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Ali, 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Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4487-1874</orcidid></search><sort><creationdate>20161201</creationdate><title>Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study</title><author>Ali, Oumer ; Aseffa, Abraham ; Omer, Ahmed Bedru ; Lema, Tsehaynesh ; Demissie, Tesfaye Moti ; Tekletsion, Yenenesh ; Worku, Alemayehu ; Xabher, Haimanot Guebre ; Yamuah, Lawrence ; Boukary, Rahamatou Moustapha ; Collard, Jean-Marc ; Dan Dano, Ibrahim ; Habiboulaye, Ibrahim ; Issaka, Bassira ; Jusot, Jean-François ; Ousmane, Sani ; Rabe, Issoufa ; Dauglaz, Doumagoum Moto ; Gami, Jean Pierre ; Gamougam, Kadidja ; Mbainadji, Lodoum ; Naibei, Nathan ; Narbé, Maxime ; Toralta, Jacques ; Berthe, Abdoulaye ; Diallo, Kanny ; Keita, Mahamadou ; Coulibaly, Adama ; Onwuchekwa, Uma ; Sow, Samba O ; Tamboura, Boubou ; Traore, Awa ; Toure, Aliou ; Clark, Tom ; Mayer, Leonard ; Amodu, Mary ; Beida, Omeiza ; Gadzama, Galadima ; Omotara, Babatunji ; Zailani, Sambo ; Yahya, Shuaibu ; Chandramohan, Daniel ; Greenwood, Brian M ; Hassan-King, Musa ; Manigart, Olivier ; Nascimento, Maria ; M Stuart, James ; Woukeu, Arouna ; Basta, Nicole E ; Bai, Xilian ; Borrow, Ray ; Findlow, Helen ; Alavo, Serge ; Bassene, Hubert ; Diallo, Aldiouma ; Dieng, Marietou ; Doucouré, Souleymane ; Gomis, Jules François ; Ndiaye, Assane ; Sokhna, Cheikh ; Trape, Jean François ; Bugri, Akalifa ; Forgor, Abudulai ; Hodgson, Abraham ; Osei, Isaac ; Quaye, Stephen L ; Williams, John ; Wontuo, Peter ; Irving, Thomas ; Trotter, Caroline L ; Karachaliou, Andromachi ; Bennett, Julia ; Hill, Dorothea ; Harrison, Odile ; Maiden, Martin C ; Rebbetts, Lisa ; Watkins, Eleanor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-2539d57bceb1508c8de156f9bb19389c9c7779756cb072ca2d9bb838c1350f613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Africa</topic><topic>Age Factors</topic><topic>Bacteriology</topic><topic>Carrier State</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Meningitis, Meningococcal</topic><topic>Meningitis, Meningococcal - diagnosis</topic><topic>Meningitis, Meningococcal - transmission</topic><topic>Microbiology and Parasitology</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - isolation & purification</topic><topic>Santé publique et épidémiologie</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Oumer</creatorcontrib><creatorcontrib>Aseffa, Abraham</creatorcontrib><creatorcontrib>Omer, Ahmed Bedru</creatorcontrib><creatorcontrib>Lema, Tsehaynesh</creatorcontrib><creatorcontrib>Demissie, Tesfaye Moti</creatorcontrib><creatorcontrib>Tekletsion, Yenenesh</creatorcontrib><creatorcontrib>Worku, Alemayehu</creatorcontrib><creatorcontrib>Xabher, Haimanot Guebre</creatorcontrib><creatorcontrib>Yamuah, Lawrence</creatorcontrib><creatorcontrib>Boukary, Rahamatou Moustapha</creatorcontrib><creatorcontrib>Collard, Jean-Marc</creatorcontrib><creatorcontrib>Dan Dano, Ibrahim</creatorcontrib><creatorcontrib>Habiboulaye, Ibrahim</creatorcontrib><creatorcontrib>Issaka, Bassira</creatorcontrib><creatorcontrib>Jusot, Jean-François</creatorcontrib><creatorcontrib>Ousmane, Sani</creatorcontrib><creatorcontrib>Rabe, Issoufa</creatorcontrib><creatorcontrib>Dauglaz, Doumagoum Moto</creatorcontrib><creatorcontrib>Gami, Jean Pierre</creatorcontrib><creatorcontrib>Gamougam, Kadidja</creatorcontrib><creatorcontrib>Mbainadji, Lodoum</creatorcontrib><creatorcontrib>Naibei, Nathan</creatorcontrib><creatorcontrib>Narbé, Maxime</creatorcontrib><creatorcontrib>Toralta, Jacques</creatorcontrib><creatorcontrib>Berthe, Abdoulaye</creatorcontrib><creatorcontrib>Diallo, Kanny</creatorcontrib><creatorcontrib>Keita, Mahamadou</creatorcontrib><creatorcontrib>Coulibaly, Adama</creatorcontrib><creatorcontrib>Onwuchekwa, Uma</creatorcontrib><creatorcontrib>Sow, Samba O</creatorcontrib><creatorcontrib>Tamboura, Boubou</creatorcontrib><creatorcontrib>Traore, Awa</creatorcontrib><creatorcontrib>Toure, Aliou</creatorcontrib><creatorcontrib>Clark, Tom</creatorcontrib><creatorcontrib>Mayer, Leonard</creatorcontrib><creatorcontrib>Amodu, Mary</creatorcontrib><creatorcontrib>Beida, Omeiza</creatorcontrib><creatorcontrib>Gadzama, Galadima</creatorcontrib><creatorcontrib>Omotara, Babatunji</creatorcontrib><creatorcontrib>Zailani, Sambo</creatorcontrib><creatorcontrib>Yahya, Shuaibu</creatorcontrib><creatorcontrib>Chandramohan, Daniel</creatorcontrib><creatorcontrib>Greenwood, Brian M</creatorcontrib><creatorcontrib>Hassan-King, Musa</creatorcontrib><creatorcontrib>Manigart, Olivier</creatorcontrib><creatorcontrib>Nascimento, Maria</creatorcontrib><creatorcontrib>M Stuart, James</creatorcontrib><creatorcontrib>Woukeu, Arouna</creatorcontrib><creatorcontrib>Basta, Nicole E</creatorcontrib><creatorcontrib>Bai, Xilian</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><creatorcontrib>Findlow, Helen</creatorcontrib><creatorcontrib>Alavo, Serge</creatorcontrib><creatorcontrib>Bassene, Hubert</creatorcontrib><creatorcontrib>Diallo, Aldiouma</creatorcontrib><creatorcontrib>Dieng, Marietou</creatorcontrib><creatorcontrib>Doucouré, Souleymane</creatorcontrib><creatorcontrib>Gomis, Jules François</creatorcontrib><creatorcontrib>Ndiaye, Assane</creatorcontrib><creatorcontrib>Sokhna, Cheikh</creatorcontrib><creatorcontrib>Trape, Jean François</creatorcontrib><creatorcontrib>Bugri, Akalifa</creatorcontrib><creatorcontrib>Forgor, Abudulai</creatorcontrib><creatorcontrib>Hodgson, Abraham</creatorcontrib><creatorcontrib>Osei, Isaac</creatorcontrib><creatorcontrib>Quaye, Stephen L</creatorcontrib><creatorcontrib>Williams, John</creatorcontrib><creatorcontrib>Wontuo, Peter</creatorcontrib><creatorcontrib>Irving, Thomas</creatorcontrib><creatorcontrib>Trotter, Caroline L</creatorcontrib><creatorcontrib>Karachaliou, Andromachi</creatorcontrib><creatorcontrib>Bennett, Julia</creatorcontrib><creatorcontrib>Hill, Dorothea</creatorcontrib><creatorcontrib>Harrison, Odile</creatorcontrib><creatorcontrib>Maiden, Martin C</creatorcontrib><creatorcontrib>Rebbetts, Lisa</creatorcontrib><creatorcontrib>Watkins, Eleanor</creatorcontrib><creatorcontrib>MenAfriCar Consortium</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>The Lancet global health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Oumer</au><au>Aseffa, Abraham</au><au>Omer, Ahmed Bedru</au><au>Lema, Tsehaynesh</au><au>Demissie, Tesfaye Moti</au><au>Tekletsion, Yenenesh</au><au>Worku, Alemayehu</au><au>Xabher, Haimanot Guebre</au><au>Yamuah, Lawrence</au><au>Boukary, Rahamatou Moustapha</au><au>Collard, Jean-Marc</au><au>Dan Dano, Ibrahim</au><au>Habiboulaye, Ibrahim</au><au>Issaka, Bassira</au><au>Jusot, Jean-François</au><au>Ousmane, Sani</au><au>Rabe, Issoufa</au><au>Dauglaz, Doumagoum Moto</au><au>Gami, Jean Pierre</au><au>Gamougam, Kadidja</au><au>Mbainadji, Lodoum</au><au>Naibei, Nathan</au><au>Narbé, Maxime</au><au>Toralta, Jacques</au><au>Berthe, Abdoulaye</au><au>Diallo, Kanny</au><au>Keita, Mahamadou</au><au>Coulibaly, Adama</au><au>Onwuchekwa, Uma</au><au>Sow, Samba O</au><au>Tamboura, Boubou</au><au>Traore, Awa</au><au>Toure, Aliou</au><au>Clark, Tom</au><au>Mayer, Leonard</au><au>Amodu, Mary</au><au>Beida, Omeiza</au><au>Gadzama, Galadima</au><au>Omotara, Babatunji</au><au>Zailani, Sambo</au><au>Yahya, Shuaibu</au><au>Chandramohan, Daniel</au><au>Greenwood, Brian M</au><au>Hassan-King, Musa</au><au>Manigart, Olivier</au><au>Nascimento, Maria</au><au>M Stuart, James</au><au>Woukeu, Arouna</au><au>Basta, Nicole E</au><au>Bai, Xilian</au><au>Borrow, Ray</au><au>Findlow, Helen</au><au>Alavo, Serge</au><au>Bassene, Hubert</au><au>Diallo, Aldiouma</au><au>Dieng, Marietou</au><au>Doucouré, Souleymane</au><au>Gomis, Jules François</au><au>Ndiaye, Assane</au><au>Sokhna, Cheikh</au><au>Trape, Jean François</au><au>Bugri, Akalifa</au><au>Forgor, Abudulai</au><au>Hodgson, Abraham</au><au>Osei, Isaac</au><au>Quaye, Stephen L</au><au>Williams, John</au><au>Wontuo, Peter</au><au>Irving, Thomas</au><au>Trotter, Caroline L</au><au>Karachaliou, Andromachi</au><au>Bennett, Julia</au><au>Hill, Dorothea</au><au>Harrison, Odile</au><au>Maiden, Martin C</au><au>Rebbetts, Lisa</au><au>Watkins, Eleanor</au><aucorp>MenAfriCar Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study</atitle><jtitle>The Lancet global health</jtitle><addtitle>Lancet Glob Health</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>4</volume><issue>12</issue><spage>e989</spage><epage>e995</epage><pages>e989-e995</pages><issn>2214-109X</issn><issn>2572-116X</issn><eissn>2214-109X</eissn><abstract>Summary Background Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. Methods Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study. We took pharyngeal swabs at first visit and took further swabs twice a month for 2 months and then monthly for a further 4 months. We used conventional bacteriological and molecular techniques to identify and characterise meningococci. We estimated the rates of carriage acquisition and recovery using a multi-state Markov model. Findings Meningococci were isolated from 241 (25%) of 980 members of 133 households in which a carrier had been identified in the cross-sectional survey or at the first household visit. Carriage was detected subsequently in another household member who was not an index carrier in 75 households. Transmission within a household, suggested by detection of a further carrier with the same strain as the index carrier, was found in 52 of these 75 households. Children younger than 5 years were the group that most frequently acquired carriage from other household members. The overall individual acquisition rate was 2·4% (95% CI 1·6–4·0) per month, varying by age and household carriage status. The mean duration of carriage was 3·4 months (95% CI 2·7–4·4). Interpretation In the African meningitis belt, transmission of meningococci within households is important, particularly for young children, and periods of carriage are usually of short duration. Funding Bill & Melinda Gates Foundation, Wellcome Trust.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27855873</pmid><doi>10.1016/S2214-109X(16)30244-3</doi><orcidid>https://orcid.org/0000-0002-4487-1874</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2214-109X |
| ispartof | The Lancet global health, 2016-12, Vol.4 (12), p.e989-e995 |
| issn | 2214-109X 2572-116X 2214-109X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_pasteur_03238489v1 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Africa Age Factors Bacteriology Carrier State Child Child, Preschool Cohort Studies Cross-Sectional Studies Family Characteristics Female Human health and pathology Humans Infant Infant, Newborn Infectious diseases Internal Medicine Life Sciences Longitudinal Studies Male Meningitis, Meningococcal Meningitis, Meningococcal - diagnosis Meningitis, Meningococcal - transmission Microbiology and Parasitology Neisseria meningitidis Neisseria meningitidis - isolation & purification Santé publique et épidémiologie |
| title | Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study |
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