Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%...

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Veröffentlicht in:	Genes chromosomes & cancer 1997-01, Vol.18 (1), p.59-65
Hauptverfasser:	Marchio, Agnès, Meddeb, Mounira, Pineau, Pascal, Danglot, Gisèle, Tiollais, Pierre, Bernheim, Alain, Dejean, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Chromosome Aberrations Chromosome Disorders Chronic Disease DNA, Neoplasm DNA, Neoplasm - analysis Gene Amplification Hepatitis B Hepatitis B - complications Humans Life Sciences Liver Neoplasms Liver Neoplasms - genetics Liver Neoplasms - virology Metaphase Nucleic Acid Hybridization Tumor Cells, Cultured
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