Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma
The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromo...
Gespeichert in:
| Veröffentlicht in: | Oncogene 1999-05, Vol.18 (20), p.3127-3134 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3134 |
|---|---|
| container_issue | 20 |
| container_start_page | 3127 |
| container_title | Oncogene |
| container_volume | 18 |
| creator | PINEAU, P NAGAI, H PRIGENT, S YU WEI GYAPAY, G WEISSENBACH, J TIOLLAIS, P BUENDIA, M.-A DEJEAN, A |
| description | The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor samples using 40 microsatellites positioned every 2 cm in average throughout 8p. We found that 60% of the tumors exhibited loss of heterozygosity (LOH) at one or more loci at 8p with three distinct minimal deleted areas: a 13 cm region in the distal part of 8p21, a 9 cm area in the more proximal portion of 8p22 and a 5 cm area in 8p23. These data strongly suggest the presence of at least three novel tumor suppressor loci on 8p in hepatocellular carcinoma. |
| doi_str_mv | 10.1038/sj.onc.1202648 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_pasteur_03237343v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2641303772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-c97cbb90c347b8965a9e6df23a9b515e81c5526bb766952a63e8b7bc1a6814ce3</originalsourceid><addsrcrecordid>eNqF0c-L1DAUB_Agiju7evUoAcVbx_xokua4LOouDHjRc0jTV5uhTcYkFda_3gwdVLx4CiSf93gvX4ReUbKnhHfv83Efg9tTRphsuydoR1slGyF0-xTtiBak0YyzK3Sd85EQojRhz9FVLW1rdbtDPx8GCMWP3tniY8BxxGVKAHjwufjgCk7wrT7k84udZ5i9wwPMULbLUDngPMVUsE3LWbkpxSXmuADusA94gpMt0cE8r7NN2NnkfIiLfYGejXbO8PJy3qCvHz98ubtvDp8_PdzdHhrXdrw0TivX95o43qq-01JYDXIYGbe6F1RAR50QTPa9klILZiWHrle9o1Z2tHXAb1Cz9Z3sbE7JLzY9mmi9ub89mJPNBdZkCGdc8Zb_oNW_2_wpxe8r5GIWn8_j2wBxzUZqpbhQ_L-QKiZZ_eUK3_wDj3FNoS5tamqUE64Uq2q_KZdizgnG38NSYs5hm3w0NWxzCbsWvL60XfsFhr_4lm4Fby_AZmfnMdngfP7jOq5J3eMX_CKzCA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2641303772</pqid></control><display><type>article</type><title>Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>PINEAU, P ; NAGAI, H ; PRIGENT, S ; YU WEI ; GYAPAY, G ; WEISSENBACH, J ; TIOLLAIS, P ; BUENDIA, M.-A ; DEJEAN, A</creator><creatorcontrib>PINEAU, P ; NAGAI, H ; PRIGENT, S ; YU WEI ; GYAPAY, G ; WEISSENBACH, J ; TIOLLAIS, P ; BUENDIA, M.-A ; DEJEAN, A</creatorcontrib><description>The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor samples using 40 microsatellites positioned every 2 cm in average throughout 8p. We found that 60% of the tumors exhibited loss of heterozygosity (LOH) at one or more loci at 8p with three distinct minimal deleted areas: a 13 cm region in the distal part of 8p21, a 9 cm area in the more proximal portion of 8p22 and a 5 cm area in 8p23. These data strongly suggest the presence of at least three novel tumor suppressor loci on 8p in hepatocellular carcinoma.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1202648</identifier><identifier>PMID: 10340384</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adult ; Alleles ; Base Sequence ; Biological and medical sciences ; Carcinoma, Hepatocellular ; Carcinoma, Hepatocellular - genetics ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromosome 8 ; Chromosome Deletion ; Chromosomes ; Chromosomes, Human, Pair 8 ; DNA Primers ; Female ; Fundamental and applied biological sciences. Psychology ; Genomes ; Hepatocellular carcinoma ; Heterozygosity ; Humans ; Life Sciences ; Liver cancer ; Liver Neoplasms ; Liver Neoplasms - genetics ; Loss of Heterozygosity ; Male ; Microsatellites ; Middle Aged ; Molecular and cellular biology ; Tumor suppressor genes ; Tumors</subject><ispartof>Oncogene, 1999-05, Vol.18 (20), p.3127-3134</ispartof><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1999.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-c97cbb90c347b8965a9e6df23a9b515e81c5526bb766952a63e8b7bc1a6814ce3</citedby><cites>FETCH-LOGICAL-c483t-c97cbb90c347b8965a9e6df23a9b515e81c5526bb766952a63e8b7bc1a6814ce3</cites><orcidid>0000-0002-0020-6549 ; 0000-0002-9407-1592 ; 0000-0002-8846-1113</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1839073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10340384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://pasteur.hal.science/pasteur-03237343$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>PINEAU, P</creatorcontrib><creatorcontrib>NAGAI, H</creatorcontrib><creatorcontrib>PRIGENT, S</creatorcontrib><creatorcontrib>YU WEI</creatorcontrib><creatorcontrib>GYAPAY, G</creatorcontrib><creatorcontrib>WEISSENBACH, J</creatorcontrib><creatorcontrib>TIOLLAIS, P</creatorcontrib><creatorcontrib>BUENDIA, M.-A</creatorcontrib><creatorcontrib>DEJEAN, A</creatorcontrib><title>Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor samples using 40 microsatellites positioned every 2 cm in average throughout 8p. We found that 60% of the tumors exhibited loss of heterozygosity (LOH) at one or more loci at 8p with three distinct minimal deleted areas: a 13 cm region in the distal part of 8p21, a 9 cm area in the more proximal portion of 8p22 and a 5 cm area in 8p23. These data strongly suggest the presence of at least three novel tumor suppressor loci on 8p in hepatocellular carcinoma.</description><subject>Adult</subject><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chromosome 8</subject><subject>Chromosome Deletion</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 8</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genomes</subject><subject>Hepatocellular carcinoma</subject><subject>Heterozygosity</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver cancer</subject><subject>Liver Neoplasms</subject><subject>Liver Neoplasms - genetics</subject><subject>Loss of Heterozygosity</subject><subject>Male</subject><subject>Microsatellites</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c-L1DAUB_Agiju7evUoAcVbx_xokua4LOouDHjRc0jTV5uhTcYkFda_3gwdVLx4CiSf93gvX4ReUbKnhHfv83Efg9tTRphsuydoR1slGyF0-xTtiBak0YyzK3Sd85EQojRhz9FVLW1rdbtDPx8GCMWP3tniY8BxxGVKAHjwufjgCk7wrT7k84udZ5i9wwPMULbLUDngPMVUsE3LWbkpxSXmuADusA94gpMt0cE8r7NN2NnkfIiLfYGejXbO8PJy3qCvHz98ubtvDp8_PdzdHhrXdrw0TivX95o43qq-01JYDXIYGbe6F1RAR50QTPa9klILZiWHrle9o1Z2tHXAb1Cz9Z3sbE7JLzY9mmi9ub89mJPNBdZkCGdc8Zb_oNW_2_wpxe8r5GIWn8_j2wBxzUZqpbhQ_L-QKiZZ_eUK3_wDj3FNoS5tamqUE64Uq2q_KZdizgnG38NSYs5hm3w0NWxzCbsWvL60XfsFhr_4lm4Fby_AZmfnMdngfP7jOq5J3eMX_CKzCA</recordid><startdate>19990520</startdate><enddate>19990520</enddate><creator>PINEAU, P</creator><creator>NAGAI, H</creator><creator>PRIGENT, S</creator><creator>YU WEI</creator><creator>GYAPAY, G</creator><creator>WEISSENBACH, J</creator><creator>TIOLLAIS, P</creator><creator>BUENDIA, M.-A</creator><creator>DEJEAN, A</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><general>Nature Publishing Group [1987-....]</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0020-6549</orcidid><orcidid>https://orcid.org/0000-0002-9407-1592</orcidid><orcidid>https://orcid.org/0000-0002-8846-1113</orcidid></search><sort><creationdate>19990520</creationdate><title>Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma</title><author>PINEAU, P ; NAGAI, H ; PRIGENT, S ; YU WEI ; GYAPAY, G ; WEISSENBACH, J ; TIOLLAIS, P ; BUENDIA, M.-A ; DEJEAN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-c97cbb90c347b8965a9e6df23a9b515e81c5526bb766952a63e8b7bc1a6814ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Chromosome 8</topic><topic>Chromosome Deletion</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 8</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genomes</topic><topic>Hepatocellular carcinoma</topic><topic>Heterozygosity</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liver cancer</topic><topic>Liver Neoplasms</topic><topic>Liver Neoplasms - genetics</topic><topic>Loss of Heterozygosity</topic><topic>Male</topic><topic>Microsatellites</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PINEAU, P</creatorcontrib><creatorcontrib>NAGAI, H</creatorcontrib><creatorcontrib>PRIGENT, S</creatorcontrib><creatorcontrib>YU WEI</creatorcontrib><creatorcontrib>GYAPAY, G</creatorcontrib><creatorcontrib>WEISSENBACH, J</creatorcontrib><creatorcontrib>TIOLLAIS, P</creatorcontrib><creatorcontrib>BUENDIA, M.-A</creatorcontrib><creatorcontrib>DEJEAN, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PINEAU, P</au><au>NAGAI, H</au><au>PRIGENT, S</au><au>YU WEI</au><au>GYAPAY, G</au><au>WEISSENBACH, J</au><au>TIOLLAIS, P</au><au>BUENDIA, M.-A</au><au>DEJEAN, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>1999-05-20</date><risdate>1999</risdate><volume>18</volume><issue>20</issue><spage>3127</spage><epage>3134</epage><pages>3127-3134</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor samples using 40 microsatellites positioned every 2 cm in average throughout 8p. We found that 60% of the tumors exhibited loss of heterozygosity (LOH) at one or more loci at 8p with three distinct minimal deleted areas: a 13 cm region in the distal part of 8p21, a 9 cm area in the more proximal portion of 8p22 and a 5 cm area in 8p23. These data strongly suggest the presence of at least three novel tumor suppressor loci on 8p in hepatocellular carcinoma.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>10340384</pmid><doi>10.1038/sj.onc.1202648</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0020-6549</orcidid><orcidid>https://orcid.org/0000-0002-9407-1592</orcidid><orcidid>https://orcid.org/0000-0002-8846-1113</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 1999-05, Vol.18 (20), p.3127-3134 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_pasteur_03237343v1 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Alleles Base Sequence Biological and medical sciences Carcinoma, Hepatocellular Carcinoma, Hepatocellular - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 8 Chromosome Deletion Chromosomes Chromosomes, Human, Pair 8 DNA Primers Female Fundamental and applied biological sciences. Psychology Genomes Hepatocellular carcinoma Heterozygosity Humans Life Sciences Liver cancer Liver Neoplasms Liver Neoplasms - genetics Loss of Heterozygosity Male Microsatellites Middle Aged Molecular and cellular biology Tumor suppressor genes Tumors |
| title | Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A31%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20three%20distinct%20regions%20of%20allelic%20deletions%20on%20the%20short%20arm%20of%20chromosome%208%20in%20hepatocellular%20carcinoma&rft.jtitle=Oncogene&rft.au=PINEAU,%20P&rft.date=1999-05-20&rft.volume=18&rft.issue=20&rft.spage=3127&rft.epage=3134&rft.pages=3127-3134&rft.issn=0950-9232&rft.eissn=1476-5594&rft_id=info:doi/10.1038/sj.onc.1202648&rft_dat=%3Cproquest_hal_p%3E2641303772%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2641303772&rft_id=info:pmid/10340384&rfr_iscdi=true |