SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes

Diabetic peripheral neuropathy (DPN) is a highly frequent and debilitating clinical complication of diabetes that lacks therapies. Cellular oxidative stress regulates post-translational modifications, including SUMOylation. Here, using unbiased screens, we identified key enzymes in metabolic pathway...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2020-09, Vol.107 (6), p.1141-1159.e7
Hauptverfasser:	Agarwal, Nitin, Taberner, Francisco J., Rangel Rojas, Daniel, Moroni, Mirko, Omberbasic, Damir, Njoo, Christian, Andrieux, Alexandra, Gupta, Pooja, Bali, Kiran K., Herpel, Esther, Faghihi, Faramarz, Fleming, Thomas, Dejean, Anne, Lechner, Stefan G., Nawroth, Peter P., Lewin, Gary R., Kuner, Rohini
Format:	Artikel
Sprache:	eng
Schlagworte:	Amputation Animal models Animals Antibodies Capsaicin receptors Cells, Cultured Citric Acid Cycle Dehydrogenases Diabetes Diabetes mellitus Diabetic Neuropathies Diabetic neuropathy Enzymes Female Ganglia, Spinal Glucose Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) Glycolysis HEK293 Cells Humans Hyperglycemia Ion channels Life Sciences Male Metabolic pathways Metabolism Mice Mice, Inbred C57BL Nociception Oxidative stress Pain Peripheral neuropathy Post-translation Proteins Proteomics Sensory neurons Sensory Receptor Cells SUMO protein Sumoylation Translation TRPV Cation Channels
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