ANALYSIS OF HUMAN IL-2/IL-2 RECEPTOR β CHAIN INTERACTIONS: MONOCLONAL ANTIBODY H2-8 AND NEW IL-2 MUTANTS DEFINE THE CRITICAL ROLE OF α HELIX-A OF IL-2

Interleukin 2 (IL-2) interacts with a receptor (IL-2R) composed of three subunits (IL-2Rα, IL-2Rβ and IL-2Rγ). IL-2Rβ plays a critical role in signal transduction. An anti-human IL-2 mAb (H2-8) produced after immunization with peptide 1-30 of IL-2 was found to recognize the region occupied by Asp20,...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1997-07, Vol.9 (7), p.488-498
Hauptverfasser:	Eckenberg, Ralph, Xu, Di, Moreau, Jean-Louis, Bossus, Marc, Mazié, Jean-Claude, Tartar, André, Liu, Xin Yuan, Alzari, Pedro M., Bertoglio, Jacques, Thèze, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Aspartic Acid Aspartic Acid - metabolism Base Sequence Binding Sites Biochemistry, Molecular Biology Bioinformatics Biological Physics Cellular Biology Chemical Sciences Computer Science Cristallography DNA Female function Humans IL-2 muteins IL-2 receptors IL-2 structure Interleukin-2 Interleukin-2 - chemistry Interleukin-2 - genetics Interleukin-2 - metabolism Leucine Leucine - metabolism Life Sciences Mice Mice, Inbred BALB C Molecular Sequence Data Mutagenesis Physics Protein Binding Protein Structure, Secondary Receptors, Interleukin-2 Receptors, Interleukin-2 - metabolism Structural Biology Structure-Activity Relationship
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