The Natural Cytotoxicity Receptor NKp46 Is Dispensable for IL-22-Mediated Innate Intestinal Immune Defense against Citrobacter rodentium

Natural cytotoxicity receptors (including NKp30, NKp44, and NKp46 in humans and NKp46 in mice) are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands. Although murine NKp46 expression (encoded by Ncr1)...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-11, Vol.183 (10), p.6579-6587
Hauptverfasser:	Satoh-Takayama, Naoko, Dumoutier, Laure, Lesjean-Pottier, Sarah, Ribeiro, Vera S. G, Mandelboim, Ofer, Renauld, Jean-Christophe, Vosshenrich, Christian A. J, Di Santo, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly Antigens, Ly - genetics Antigens, Ly - immunology Antigens, Ly - metabolism Citrobacter rodentium Citrobacter rodentium - immunology Cytokines Cytokines - immunology Cytokines - metabolism DNA-Binding Proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Enterobacteriaceae Infections Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - microbiology Immunity, Innate Immunology Interleukin-22 Interleukins Interleukins - immunology Interleukins - metabolism Intestine, Small Intestine, Small - immunology Intestine, Small - metabolism Intestine, Small - microbiology Killer Cells, Natural Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - microbiology Life Sciences Lymphocyte Activation Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Natural Cytotoxicity Triggering Receptor 1 Natural Cytotoxicity Triggering Receptor 1 - genetics Natural Cytotoxicity Triggering Receptor 1 - immunology Natural Cytotoxicity Triggering Receptor 1 - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Spleen Spleen - cytology Spleen - immunology Spleen - metabolism Spleen - microbiology
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