Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment

Pharmacological activation of nicotinic acetylcholine receptors (nAChRs) exerts neuroprotective effects in cultured neurons and the intact animal. Much less is known about a physiological protective role of nAChRs. To understand whether endogenous activation of β2* nAChRs contributes to the maintena...

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Veröffentlicht in:	The FASEB journal 2007-12, Vol.21 (14), p.4028-4037
Hauptverfasser:	Zanardi, Alessio, Ferrari, Rosaria, Leo, Giuseppina, Maskos, Uwe, Changeux, Jean-Pierre, Zoli, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Behavior, Animal - drug effects Behavior, Animal - physiology Environment Design Environmental Sciences Exploratory Behavior Exploratory Behavior - drug effects Exploratory Behavior - physiology fear conditioning Female Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Life Sciences Male Maze Learning Maze Learning - drug effects Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Knockout Morris water maze Neurotoxins Neurotoxins - administration & dosage Neurotoxins - toxicity nicotinic subunit knockout mice Protein Binding Protein Binding - genetics Quinolinic Acid Quinolinic Acid - administration & dosage Quinolinic Acid - toxicity Receptors, Nicotinic Receptors, Nicotinic - deficiency Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology
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