Peptides Targeting the PDZ Domain of PTPN4 Are Efficient Inducers of Glioblastoma Cell Death

PTPN4, a human tyrosine phosphatase, protects cells against apoptosis. This protection could be abrogated by targeting the PDZ domain of this phosphatase with a peptide mimicking the C-terminal sequence of the G protein of an attenuated rabies virus strain. Here, we demonstrate that glioblastoma dea...

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Veröffentlicht in:	Structure (London) 2011-10, Vol.19 (10), p.1518-1524
Hauptverfasser:	Babault, Nicolas, Cordier, Florence, Lafage, Mireille, Cockburn, Joseph, Haouz, Ahmed, Prehaud, Christophe, Rey, Félix A., Delepierre, Muriel, Buc, Henri, Lafon, Monique, Wolff, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemistry, Molecular Biology Cell Death Cell Line, Tumor Flow Cytometry Glioblastoma - metabolism Glioblastoma - pathology Humans Life Sciences Magnetic Resonance Spectroscopy Molecular Sequence Data Multiprotein Complexes - metabolism PDZ Domains Peptides - pharmacology Point Mutation Protein Binding Protein Structure, Secondary Protein Tyrosine Phosphatase, Non-Receptor Type 4 - metabolism Rabies virus - chemistry Receptors, N-Methyl-D-Aspartate - metabolism Sequence Alignment Structural Biology Viral Proteins - chemical synthesis Viral Proteins - pharmacology
Online-Zugang:	Volltext
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